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Barshop Institute for Longevity and Aging Studies

Z. David Sharp, Ph.D.

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Z. David Sharp, Ph.D.

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Professor and Department Chairman
Department of Molecular Medicine
Barshop Institute for Longevity and Aging Studies
University of Texas Health Science Center at San Antonio
Phone: 210-567-7226

RESEARCH

We explore novel strategies to prevent diseases while mitigating morbidities associated with aging, thereby reducing suffering and looming economic burden. Toward this end, we study how chronic mTOR inhibition prevents, delays, and/or reduces the severity of cancer while mitigating other negative effects of aging. Our published proof of concept experiments show this is possible with our novel enteric formulation of rapamycin, eRapa. Our current research goals aim to understand the mechanism of action of eRapa in the prevention of colon cancer using mouse models combined with genetic, epigenetic and protein synthesis profiling technologies.

Selected Publications

Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD. eRapa restores a normal life span in a FAP mouse model. Cancer Prev Res (Phila). 2014 Jan;7(1):169-78.

Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, Van Roekel S, Winkleman L, Strong R. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell. 2013 Dec 17. doi: 10.1111/acel.12194.

Note: The below three papers tested my proposal to the NIA-ITP that chronic rapamycin treatment mitigates aging and age-related diseases thereby extending maximum longevity. 

Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors. Aging (Albany NY). 2013 Feb;5(2):100-10.

Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201.

Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009 Jul 16;460(7253):392-5.


 
 
   
 
BarshopINSTITUTElogo _Converted_
The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110

Contact: barshopinstitute@uthscsa.edu
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