University: We Make Lives Better

Barshop Institute for Longevity and Aging Studies

Paula K. Shireman, M.D.

Return

Paula K. Shireman, M.D.

Photo
Professor and Vice Dean for Team Science
Department of Surgery
Department of Microbiology & Immunology
University of Texas Health Science Center San Antonio
South Texas Veterans Health Care System
Phone: 210-567-0611

RESEARCH

Our lab studies the role of bone marrow-derived cells in angiogenesis and skeletal muscle regeneration and how aging affects these phenomena. Macrophage polarization states exhibit different functions in muscle regeneration. MicroRNAs (miRNAs) are small, noncoding RNAs that inhibit gene expression, thereby regulating many processes, including immune cell differentiation. However, the regulating effect of miRNAs on macrophage polarization, and the subsequent effect on muscle regeneration, has not been elucidated. As a clinically active vascular surgeon, my long term goal is to develop therapies to enhance muscle regeneration and tissue engineering, thereby reducing limb amputations. Modulating macrophage polarization could become a therapeutic intervention in muscle regeneration and disease states associated with acute and chronic inflammation.

Selected Publications

Wang H, Melton DW, Porter L, Sarwar ZU, McManus LM, Shireman PK. Altered macrophage phenotype transition impairs skeletal muscle regeneration. Am J Pathol. 2014 Apr;184(4):1167-84.

Chen Y, Melton DW, Gelfond JA, McManus LM, Shireman PK. MiR-351 transiently increases during muscle regeneration and promotes progenitor cell proliferation and survival upon differentiation. Physiol Genomics. 2012 Nov 1;44(21):1042-51.

Chen Y, Gelfond J, McManus LM, Shireman PK. Temporal microRNA expression during in vitro myogenic progenitor cell proliferation and differentiation: regulation of proliferation by miR-682. Physiol Genomics. 2011 May 1;43(10):621-30.

Martinez CO, McHale MJ, Wells JT, Ochoa O, Michalek JE, McManus LM, Shireman PK. Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment. Am J Physiol Regul Integr Comp Physiol. 2010 Sep;299(3):R832-42.

Sun D, Martinez CO, Ochoa O, Ruiz-Willhite L, Bonilla JR, Centonze VE, Waite LL, Michalek JE, McManus LM, Shireman PK. Bone marrow-derived cell regulation of skeletal muscle regeneration. FASEB J. 2009 Feb;23(2):382-95.


 
 
   
 
BarshopINSTITUTElogo _Converted_
The Sam and Ann Barshop Institute for Longevity and Aging Studies

15355 Lambda Drive
San Antonio, Texas  78245
P: 210-562-6140 F: 210-562-6110

Contact: barshopinstitute@uthscsa.edu
Copyright © 2016
UT Health Science Center

The University of Texas Health Science Center
Accessibility | Public/Personal Information | Site Information | Web Privacy

Links from web sites affiliated with The University of Texas Health Science Center's web site (www.uthscsa.edu) to other web sites do not constitute or imply university endorsement of those sites, their content, or products and services associated with those sites.

Site Developed by Toolbox Studios, Inc.