Failure to maintain genetic stability can result in a variety of biological outcomes potentially including aging, cancer, birth defects and reproductive failure. Our research approach is multidisciplinary involving stem cell biology, reproductive biology, aging, cancer, genetics, and cell and molecular biology to address the role of DNA repair and mutagenesis in sustaining normal biological functions.
Danhan Wang; Hui Gao; Abhik Bandyopadhyay; Anqi Wu; I.-Tien Yeh; Yidong Chen; Yi Zou; Changjiang Huang; Christi A. Walter; Qiaoxiang Dong; et al. Pubertal bisphenol A exposure alters murine mammary stem cell function leading to early neoplasia in regenerated glands Cancer Prevention Research. 2014;7(4):445-455.
Guogang Xu; C. Alex McMahan; Christi A. Walter Early-life exposure to benzo[a]pyrene increases mutant frequency in spermatogenic cells in adulthood PLoS ONE. 2014;9(1).
Qiaoxiang Dong; Danhan Wang; Abhik Bandyopadhyay; Hui Gao; Karla M. Gorena; Kim Hildreth; Vivienne I. Rebel; Christi A. Walter; Changjiang Huang; Lu-Zhe Sun Mammospheres from murine mammary stem cell-enriched basal cells: Clonal characteristics and repopulating potential Stem Cell Research. 2013;10(3):396-404