We are interested in a comprehensive understanding of mitochondrial function at the molecular, cellular, tissue, and animal levels. Mitochondria play a central role in cellular energy and also regulate apoptosis, signal transduction and cell growth. Mitochondrial defects have been reported in a wide range of conditions, such as diabetes, neurodegenerative diseases, cancers, and aging. The central theme in the laboratory is to investigate the regulatory mechanisms working in mitochondria and the role of mitochondria in regulating various cellular pathways. In particular, we are interested in the dynamics of the machinery for oxidative phosphorylation, the role of mitochondrial dysfunction in human diseases including cancer and aging process. various approaches are also explored in restoring the mitochondrial function in cells with mitochondrial deficiency.
Li Y, Li HZ, Hu P, Deng J, Banoei MM, Sharma LK, Bai Y. Generation and bioenergetic analysis of cybrids containing mitochondrial DNA from mouse skeletal muscle during aging. Nucleic Acids Res. 2010 Apr;38(6):1913-21.
Acin-Perez R, Gatti DL, Bai Y, Manfredi G. Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. Cell Metab. 2011 Jun 8;13(6):712-9.
Sharma LK, Fang H, Liu J, Vartak R, Deng J, Bai Y. Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation. Hum Mol Genet. 2011 Dec 1;20(23):4605-16.
Chen LY, Zhang Y, Zhang Q, Li H, Luo Z, Fang H, Kim SH, Qin L, Yotnda P, Xu J, Tu BP, Bai Y, Songyang Z. Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control. Mol Cell. 2012 Sep 28;47(6):839-50.
Li H, Kumar Sharma L, Li Y, Hu P, Idowu A, Liu D, Lu J, Bai Y. Comparative bioenergetic study of neuronal and muscle mitochondria during aging. Free Radic Biol Med. 2013 Oct;63:30-40.