Aging is associated with a progressive loss of muscle mass characterized by a loss of muscle fibers and fiber atrophy that lead to functional impairments in the aging population, which significantly reduces the quality of life and increases the risk of morbidity and mortality in the elderly. Despite the universal prevalence of age-related loss of muscle mass and function (sarcopenia), the biochemical and molecular mechanisms responsible are not well understood. This laboratory's major interest is to determine whether the age-related increase in inflammatory pathways and oxidative stress play a causative role in sarcopenia and to understand the interplay between inflammatory pathways and oxidative stress in skeletal muscle. In particular, this group is interested in studying the role of pathways that generate lipid mediators (e.g., cytosolic phospholipase A2, 5-lipoxygenase, and 12/15-lipoxygenases, etc.) in sarcopenia. The second interest of the laboratory is to understand the role of lipoxygenases (5- and 12/15-) on the onset and progression of the neurodegenerative disease, Amyotrophic Lateral Sclerosis.
Bhattacharya A, Wei R, Hamilton RT, Chaudhuri AR. (2014) Neuronal cells but not muscle cells are resistant to oxidative stress mediated protein misfolding and cell death: Role of molecular chaperones. Biochem Biophys Res Commun. 2014 Apr 18;446(4):1250-4.
Bhattacharya A, Hamilton R, Jernigan A, Zhang Y, Sabia M, Rahman MM, Li Y, Wei R, Chaudhuri A, Van Remmen H. (2014) Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy. Free Radic Biol Med. 2014 Feb;67:30-40.
Wei R, Bhattacharya A, Hamilton RT, Jernigan AL, Chaudhuri AR. (2013) Differential effects of mutant SOD1 on protein structure of skeletal muscle and spinal cord of familial amyotrophic lateral sclerosis: role of chaperone network. Biochem Biophys Res Commun. 2013 Aug 16;438(1):218-23.
Pulliam DA, Bhattacharya A, Van Remmen H. (2013) Mitochondrial dysfunction in aging and longevity: a causal or protective role? Antioxid Redox Signal. 2013 Oct 20;19(12):1373-87.