The Kokovay lab studies mechanisms that regulate adult neurogenesis and neural stem cell quiescence, activation, migration and differentiation. Neural stem cells are tightly regulated by the surrounding microenvironment. The major focus of the lab is to understand how different cellular compartments within the microenvironment influence neural stem cells under normal homeostasis and in the context of injury and aging. The vasculature is a known regulator of neural stem cells and we are studying how secreted molecules from endothelial cells regulate proliferation and migration of neural stem cells. We are also interested in the role immune cells play in regulating neural stem cell function and dysfunction seen during aging.
Kokovay E, Wang Y, Kusek G, Wurster R, Lederman P, Lowry N, Shen Q, Temple S. VCAM1 Is Essentialto Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensorto Regulate SVZ Lineage Progression. Cell Stem Cell. 2012 Aug 3;11(2):220-30.
Winter M, Wait E, Roysam B, Goderie SK, Ali RA, Kokovay E, Temple S, Cohen AR. Vertebrate neuralstem cell segmentation, tracking and lineaging with validation and editing. Nat Protoc. 2011 Nov 17;6(12):1942-52.
Kokovay E, Goderie S, Wang Y, Lotz S, Lin G, Sun Y, Roysam B, Shen Q, Temple S. Adult SVZ lineagecells home to and leave the vascular niche via differential responses toSDF1/CXCR4 signaling. Cell Stem Cell. 2010 Aug 6;7(2):163-73.
Fasano CA, Phoenix TN, Kokovay E, Lowry N, Elkabetz Y, Dimos JT, Lemischka IR, Studer L, Temple S. Bmi-1 cooperateswith Foxg1 to maintain neural stem cell self-renewal in the forebrain. Genes Dev. 2009 Mar 1;23(5):561-74.
Kokovay E, Shen Q, Temple S. The incredibleelastic brain: how neural stem cells expand our minds. Neuron. 2008 Nov 6;60(3):420-9.
Shen Q, Wang Y, Kokovay E, Lin G, Chuang SM, Goderie SK, Roysam B, Temple S. Adult SVZ stem cellslie in a vascular niche: a quantitative analysis of niche cell-cellinteractions. Cell Stem Cell. 2008 Sep 11;3(3):289-300.