My expertise is in clinical Geriatrics and the use of the nematode, Caenorhabditis elegans in aging research. I am particularly interested in the roles of metabolism in the aging process. Specific projects in the lab include: (1) examining how metabolic stress alters proteasomal function and expression, (2) exploring how mitochondrial function changes during aging via non-invasive techniques, (3) determining how amino acids can impair insulin-like signaling, and (4) testing whether oxidative stress responses are controlled by both cell autonomous and non-autonomous mechanisms.
Ferguson AA, Roy S, Kormanik KN, Kim Y, Dumas KJ, Ritov VB, Matern D, Hu PJ, Fisher AL. (2013) TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans. PLoS Genet. 2013 Dec;9(12):e1004020.
Ferguson AA, Cai L, Kashyap L, Fisher AL. (2013) Improved vectors for selection of transgenic Caenorhabditis elegans. Methods Mol Biol 2013 Jan;940:87-102.
Kashyap L, Perera S, Fisher AL. (2013) Identification of novel genes involved in sarcopenia through RNAi screening in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 2012 Jan;67(1):56-65.
Cai L, Phong BL, Fisher AL, Wang Z. (2011) Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes. J Biol Chem 2011 Oct;286(41):35915-35921.