My research is focused on elucidating the mechanism of bone remodeling and bone regeneration following age- and disease-induced fracture healing. We investigate the mechanism of BMP-2-induced active osteoclast formation, a fairly new concept with very limited available mechanistic details. My research is also directed to elucidate the mechanism of breast cancer growth and subsequent bone metastasis. We investigate the mechanism of inhibition of active osteoclast formation and breast cancer cell migration by omega-3 fatty acids and statin group of drugs.
Amit Bera; Falguni Das; Nandini Ghosh-Choudhury; Xiaonan Li; Sanjay Pal; Yves Gorin; Balakuntalam S. Kasinath; Hanna E. Abboud; Goutam Ghosh Choudhury A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF American Journal of Physiology - Cell Physiology. 2014;306(11):C1089-C1100.
Falguni Das; Nandini Ghosh-Choudhury; Amit Bera; Nirmalya Dey; Hanna E. Abboud; Balakuntalam S. Kasinath; Goutam Ghosh Choudhury Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy Journal of Biological Chemistry. 2013;288(11):7756-7768.
Falguni Das; Nandini Ghosh-Choudhury; Amit Bera; Balakuntalam S. Kasinath; Goutam Ghosh Choudhury TGFβ-induced PI 3 kinase-dependent Mnk-1 activation is necessary for Ser-209 phosphorylation of eIF4E and mesangial cell hypertrophy Journal of Cellular Physiology. 2013;228(7):1617-1626.