The goal of our work is to reconstitute tissue-specific stem cell niche in vitro to control stem cell fate for tissue regenerative purposes.
Antebi B, Cheng X, Harris JN, Gower LB, Chen XD, Ling J.Biomimetic collagen-hydroxyapatite composite fabricated via a novel perfusion-flow mineralization technique.Tissue Eng Part C Methods. 2013 Jul;19(7):487-96.
Sun Y, Li W, Lu Z, Chen R, Ling J, Ran Q, Jilka RL, Chen XD. Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix. FASEB J. 2011 May;25(5):1474-85.
Lai Y, Sun Y, Skinner CM, Son EL, Lu Z, Tuan RS, Jilka RL, Ling J, Chen XD. Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells. Stem Cells Dev. 2010 Jul;19(7):1095-107.
Chen XD. Extracellular matrix provides an optimal niche for the maintenance and propagation of mesenchymal stem cells.Birth Defects Res C Embryo Today. 2010 Mar;90(1):45-54.
Chen XD, Dusevich V, Feng JQ, Manolagas SC, Jilka RL. Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts. J Bone Miner Res. 2007 Dec;22(12):1943-56.