Our laboratory studies information processing in the hippocampal formation, a limbic structure crucial for encoding and the retrieval of episodic and semantic memory. We are interested in hippocampal function from a dynamical and cognitive/systems approach, and are exploring the predictions of current computational theories of brain function using behavioral, neurophysiological, neuropharmacological and molecular approaches. Presently we are investigating the dual roles of the dentate and CA3 region in encoding, pattern completion/retrieval, as well as investigating novelty detection in the hippocampal formation, and the contribution of LTP, LTD, metaplasticity and theta rhythm to hippocampal encoding processes.
Martinez, C.O., Do, VH, Derrick, B.E. (2011) Opioid peptides contribute to associative LTP in the hippocampal CA3 region in vivo. Neurobio. Learning & Mem, 96(2):207-17.
Villarreal DM, C.J. Schindler, B. Derrick, and I. Vathy (2009) Prenatal morphine exposure attenuates long-term potentiation in lateral perforant path projections to the dentate gyrus and the CA3 region in vivo. J. Neurophys 99(3): 1235-1242.
Villarreal DM, Gross A, B.E. Derrick (2007) Modulation of CA3 afferent by theta rhythm phase and novelty. J. Neurosci. 27(48):13457-13467.