Dr. Espinoza's research focuses on understanding the geriatric syndrome of frailty, an important clinical geriatric syndrome that causes older adults to be at risk for falls, disability, nursing home placement, and death. She studies the epidemiology of frailty, including prevalence, incidence, and predictors of frailty in the San Antonio Longitudinal Study of Aging (SALSA), in collaboration with Helen Hazuda, Ph.D., the Principal Investigator of SALSA. She also conducts research investigating the pathophysiology of frailty, focusing on screening the plasma glycoproteome for potential biomarkers of frailty. Her work has led to a four-year, Harold Amos Medical Faculty Development Award sponsored by the Robert Wood Johnson Foundation as well as a VISN 17 New Investigator Award. Dr. Espinoza is also the Site Principal Investigator for ASPREE (Aspirin for the Prevention of Events in the Elderly) an international, multicenter NIH/NIA funded study of low-dose aspirin for the prevention of cognitive decline and physical
disability in health older adults.
Darvin K, Randolph A, Ovalles S, Halade D, Breeding L, Richardson A, Espinoza SE. (2014) Plasma Protein Biomarkers of the Geriatric Syndrome of Frailty. Journals of Gerontology Series A: Medical and Biological Sciences 2014 Feb;69A(2):182-186.
Pugh JA, Wang C-P, Espinoza S, Noel PH, Bollinger M, Amuan M, Finley E, Pugh MJ. (2014) Influence of Frailty Diagnoses, Inappropriate Prescribing and Primary Care Utilization on fewer than 30-Day Readmissions for Veterans over 65 Years of Age. In press: Journal of the American Geriatrics Society 2014 Feb;62(2):291-8.
ASPREE Investigator Group.(2013) Study design of ASPirin in Reducing Events in the Elderly (ASPREE): A randomized, controlled trial. Contemporary Clinical Trials 2013 Nov;36(2):555-564.
Garcia C, Espinoza SE, Lichtenstein M, Hazuda H. (2013) Health Literacy Associations between Hispanic Elderly Patients and their Caregivers.Journal of Health Communication 2013 Oct;18:256-272.