My laboratory is interested in the role played by the endocannabinoid system in regulating psychomotor functions. The endocannabinoids are a family of naturally occurring lipids that mimic the effects of marijuana by stimulating specific receptors (cannabinoid receptors) epressed in the brain areas that are critical for the regulation of motor behaviors, such as the basal ganglia. In addition, the endocannabinoids may serve as an inhibitory feedback signal to counteract dopamine-induced motor activation. Our studies indicate that the endocannabinoid system represents a new pharmacological target for the treatment of diseases characterized by dysregulation of dopamine transmission, such as Parkinson's disease and schizophrenia.
Raichlen DA, Foster AD, Seillier A, Giuffrida A, Gerdeman GL. Exercise-induced endocannabinoid signaling is modulated by intensity. Eur J Appl Physiol. 2013 Apr;113(4):869-75.
Seillier A, Martinez AA, Giuffrida A. Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CBâ receptors: implications for schizophrenia. Neuropsychopharmacology. 2013 Aug;38(9):1816-24.
Martinez A, Macheda T, Morgese MG, Trabace L, Giuffrida A. The cannabinoid agonist WIN55212-2 decreases L-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated rats. Neurosci Res. 2012 Mar;72(3):236-42.
Raichlen DA, Foster AD, Gerdeman GL, Seillier A, Giuffrida A. Wired to run: exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the 'runner's high'. J Exp Biol. 2012 Apr 15;215(Pt 8):1331-6.
Gould GG, Seillier A, Weiss G, Giuffrida A, Burke TF, Hensler JG, Rock C, Tristan A, McMahon LR, Salazar A, O'Connor JC, Satsangi N, Satsangi RK, Gu TT, Treat K, Smolik C, Schultz ST. Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):260-9.