University: We Make Lives Better

Barshop Institute for Longevity and Aging Studies

Peter Hornsby, PhD


Peter Hornsby, PhD

Professor of Physiology
Department of Physiology and the Barshop Institute
Barshop Institute for Longevity and Aging Studies
University of Texas Health Science Center at San Antonio
Office: 210-562-5080


Many individuals, especially the elderly, may benefit from the application of regenerative medicine to the therapy of human disease. In the future, regenerative medicine may offer better regeneration of organs that have suffered damage from trauma or other events, and better approaches to the therapy of degenerative diseases that impair function and shorten life in older individuals. An important discovery for regenerative medicine is induced pluripotent stem (iPS) cells. iPS cells are like embryonic stem cells, yet can be derived from any adult cell, such as a skin cell. When iPS cells are derived from the skin cells of a individual patient, they should be able to be transplanted back to the same patient without rejection. Before this is applied to human patients, the properties of iPS cells must be thoroughly explored in suitable animal models, to make sure that autologous cell therapy is both safe and effective. For this purpose nonhuman primates are ideal, because of their relatedness to humans and their similar central nervous systems.


Qiu, Z.; Farnsworth, S.L.; Mishra, A.; Hornsby PJ. (2013) Patient-specific induced pluripotent stem cells in neurological disease modeling: The importance of nonhuman primate models. Stem Cells and Cloning: Advances and Applications 6: 19-29.

Farnsworth, S.L.; Qiu, Z.; Mishra, A.; Hornsby PJ. (2013) Directed neural differentiation of induced pluripotent stem cells from non-human primates.Exp. Biol. Med. 2013 238: 276-284.

Wu Y, Zhang Y, Mishra A, Tardif SD, Hornsby PJ. (2010) Generation of induced pluripotent stem cells from newborn marmoset skin fibroblasts. Stem Cell Res. 2010 May;4(3):180-8.



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The Sam and Ann Barshop Institute for Longevity and Aging Studies

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