Over the past 20 years, I have been directly responsible for the pathological analyses of all animals studied in multiple Program Projects and the San Antonio Nathan Shock Aging Center. In addition to pathological analyses of aging animals, I also have multiple research projects that seek the underlying mechanisms of aging. The primary goal of my research is to test whether changes in oxidative stress and redox status in the cell attenuate aging and age-related pathology, e.g., cancer, obesity, and type-2 diabetes, using unique animal models with altered levels of various antioxidant enzymes, e.g., thioredoxin transgenic/knockout mice, Cu/ZnSOD transgenic rats.
Flores, L.C., Ortiz, M., Dube, S., Hubbard, G.B., Lee, S., Salmon, A., Zhang, Y., and Ikeno, Y. Thioredoxin, oxidative stress, cancer and aging. Longevity & Healthspan. 1:4, 2012.
Pérez VI, Cortez LA, Lew CM, Rodriguez M, Webb CR, Van Remmen H, Chaudhuri A, Qi W, Lee S, Bokov A, Fok W, Jones D, Richardson A, Yodoi J, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y. Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice. J Gerontol A Biol Sci Med Sci. 2011 Dec;66(12):1286-99.
Ikeno Y, Hubbard GB, Lee S, Cortez LA, Lew CM, Webb CR, Berryman DE, List EO, Kopchick JJ, Bartke A. Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci. 2009 May;64(5):522-9.
Ikeno Y, Hubbard GB, Lee S, Richardson A, Strong R, Diaz V, Nelson JF. Housing density does not influence the longevity effect of calorie restriction. J Gerontol A Biol Sci Med Sci. 2005 Dec;60(12):1510-7.
Ikeno Y, Bronson RT, Hubbard GB, Lee S, Bartke A. Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity.J Gerontol A Biol Sci Med Sci. 2003 Apr;58(4):291-6.