The Jiang’s research focuses on understanding the molecular mechanism of intercellular and intracellular signaling mediated by connexin channels and the functional importance of these channels in the lens, skeletal tissues and cancer metastasis. The ongoing research projects include: 1. Channel-dependent and –independent roles of connexins in lens differentiation and development, and in maintaining lens transparency; 2. Connexin hemichannels and integrins in mediating mechanotransduction process in osteocytes and bone tissues and in protecting cells against oxidative stress; 3. Connexin channels in suppression of cancer metastasis; 4. Structure-function of amino acid transporters and their roles in neurodegeneration and oxidative stress. Various biochemical, molecular, cellular and genetic approaches as well as cell and transgenic mouse models are established to address these questions.
Zhou JZ, Riquelme MA, Ellies LG, Sun L-Z, Jiang JX. Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis. Oncogene (in press).
Batra N, Riquelme MA, Burra S, Jiang JX. 14-3-3θ facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels. J Cell Sci. 2014 Jan 1;127(Pt 1):137-46.
Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX. Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3359-64.
Shi Q, Padmanabhan R, Villegas CJ, Gu S, Jiang JX. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. J Biol Chem. 2011 Nov 4;286(44):38086-94.
Burra S, Nicolella DP, Francis WL, Freitas CJ, Mueschke NJ, Poole K, Jiang JX. Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13648-53.