Using a molecular genetic approach, Dr. Leach studies a number of diseases including prostate and testicular cancers, diabetes, schizophrenia and Paget's disease of the bone. The genetic studies have used both molecular techniques and epidemiological approaches. These studies are conducted with numerous collaborators from the health science center as well as other institution. In addition, her laboratory has been involved in identify novel cancer biomarkers primarily for prostate cancer. Dr. Leach works closely with Dr. Ian Thompson. Dr. Thompson is the chair of the Department of Urology and is also the cancer center director. Drs. Thompson and Leach have been part of the Early Detection Research Network from the National Cancer Institute. Dr. Thompson currently has a large cohort study which involves screening men for prostate cancer in the San Antonio area. Dr. Leach has directed several research studies on this population.
Blackburn A, Wilson D, Gelfond J, Yao L, Hernandez J, Thompson IM, Leach RJ, Lehman DM. Validation of copy number variants associated with prostate cancer risk and prognosis. Urol Oncol. 2014 Jan;32(1):44.e15-20.
Medina EA, Shi X, Grayson MH, Ankerst DP, Livi CB, Medina MV, Thompson IM Jr, Leach RJ. The diagnostic value of adiponectin multimers in healthy men undergoing screening for prostate cancer. Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):309-15.
Marballi KK, McCullumsmith RE, Yates S, Escamilla MA, Leach RJ, Raventos H, Walss-Bass C. Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches. J Neural Transm. 2014 Jan 1.
Gonzalez S, Xu C, Ramirez M, Zavala J, Armas R, Contreras SA, Contreras J, Dassori A, Leach RJ, Flores D, Jerez A, Raventós H, Ontiveros A, Nicolini H, Escamilla M. Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in Latinos: a family-based association study. Bipolar Disord. 2013 Mar;15(2):206-14.
Thompson IM Jr, Leach R. Prostate cancer and prostatic intraepithelial neoplasia: true, true, and unrelated? J Clin Oncol. 2013 Feb 10;31(5):515-6.