My Research Interests:
Mechanisms of healthy brain aging.
Why I’m Excited to Study Aging:
Aging is, in my view, the most interesting and ubiquitous aspect of biological existence. Most mammals will experience years to decades of life, wherein the strength and vitality of youth fade, and are replaced by disease and the inevitable failure of the physical body. It is at the intersection of aging and brain health that I find my greatest passion in science, and where I will focus my research throughout my career. I approach the study of aging with the understanding that death is as much a part of life as birth, and is essential and inevitable, but that quality of life can be improved with a better understanding of the aging process and how to rapidly implement our basic scientific findings in the growing geriatric population.
My Future Goals:
I hope to utilize the skills I have gained in graduate school to advocate for funding dedicated to addressing the extensive questions on the neuroscience of aging. I am passionate about promoting science literacy and education in community settings to better communicate with the public regarding the critical research that must be done to improve quality of life as we age.
Awards and Honors:
- 2015 T32 Biology of Aging Training Grant
- 2015 Association for Clinical and Translational Science Research Day Poster Award
- 2015 American Aging Association Travel Award Winner
- 2015 Center for Biomedical Neuroscience Poster Award
- 2014 Training Fellowship, Institutional National Research Service Award, Translational Science Program (TL1)
- 2012 Serotonin Club Travel Award Recipient
- 2012 Serotonin Club "Pioneers and Prodigies" Speaker
- 2012 ASPET Graduate Student Poster Competition, First Place-Neuropharmacology Division
- 2012 ASPET Graduate Student Travel Award
- 2011 Society for Neuroscience-Alamo Chapter, First Place Poster Presentation - Graduate Student
- 2010 Graduate Dean's Award
Horton, RE; Apple DM; Owens WA; Baganz NL; Cano S; Mitchell NC' Vitela M; Gould GG; Koek W; Daws LC. Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: Uncovering novel targets to treat depression. The Journal of Neuroscience, 19 June 2013,33(25):10534-10543
Chotibut, T; Apple DM; Jefferis R; Salvatore, MF. Dopamine transporter loss in 6-OHDA Parkinson's model is unmet by parallel reduction in dopamine uptake. PLoS One. 2012; 7(12): e52322
Apple DM; Solano Fonseca R; Kokovay E. The role of adult neurogenesis in psychiatric and cognitive disorders. Brain Research. 19 Jan 2016; doi: 10.1016/j.brainres.2016.01.023
Solano Fonseca, R; Mahesula S, Apple DM, Raghunathan R, Dugan A, Cardona A, O’Connor J, Kokovay E. Neurogenic niche microglia undergo positional remodeling and progressive activation contributing to age-associated reductions in neurogenesis. Stem Cells and Development. 1 Apr 2016; 1;25(7):542-55