1. Postdoctoral positions are now available from a National Institute on Aging Training Grant to work with one of some 25 participating faculty. Contact Nicolas Musi, MD for information. A list of participating faculty with links to their contact information and individual Web pages may be found in the far right column. For more information regarding application requirements for this postdoctoral fellowship, link here: NIA Biology of Aging Training Grant.
U.S. Citizenship or Permanent Resident Required.
Cell Metabolism, Diabetes, and Aging
Two postdoctoral positions are available at Barshop Aging Institute of University of Texas Health Science Center at San Antonio, a leading institute in aging research, to work in the areas of signal transduction, cell metabolism, obesity, diabetes, fatty liver disease, and aging. Our ongoing research focuses on the nutrient regulation of glucose/lipid metabolism and energy balance, as well as the identification of therapeutic mechanisms for fatty liver disease and insulin resistance in diabetes and aging-related metabolic disease (Li Y, et al. Cell Metabolism, 2011; Gastroenterology, 2014; Luo T, et al. Diabetes, 2016). We generate a variety of genetically-modified mouse models and human disease-related animal models including obesity, non-alcoholic fatty liver disease, and aging-related metabolic diseases. The ideal candidate are exceptionally motivated, creative, and committed to scientific discovery and have strong academic training in biochemistry, molecular and cell biology, and animal models. Candidates with a strong background in metabolism, ER stress or autophagy biology are strongly encouraged to apply for the positions. To apply, please submit a cover letter to Dr. Mengwei Zang’s email: Zang@uthscsa.edu and attach: curriculum vitae, a one-page personal statement describing your scientific accomplishments and research interests, and contact information (including phone numbers) of three references. For more information on the research work of Zang laboratory, please visit the following website: http://molecularmedicine.uthscsa.edu/FAC_Profile.aspx?facID=210
Biological mechanisms of aging-related neurodegenerative disorders
An NIH-funded postdoctoral position for the study of neurodegenerative disorders is immediately available in the laboratory of Dr. Bess Frost at the vibrant Barshop Aging Institute of the University of Texas Health Science Center in San Antonio, TX (http://barshop.uthscsa.edu/main/about/overview). The Barshop is a leading institute for aging research, as evidenced by Pepper Center and Nathan Shock Center grants from the National Institute on Aging. The Frost laboratory studies fundamental processes in cell biology that drive neurodegeneration. We employ a multi-system approach to rapidly identify, test, and validate hypotheses that are relevant to human disease (Frost, B., M. Hemberg, J. Lewis and M. B. Feany (2014). "Tau promotes neurodegeneration through global chromatin relaxation." Nat Neurosci 17(3): 357-366.). Early discovery takes place in Drosophila, a model organism that is well suited for investigating issues of causality in disease processes. To determine if our studies are relevant to human disease, we complement Drosophila work with comparative analyses in postmortem human brain.
For more information on the research interests of our laboratory, please visit: http://www.barshop.uthscsa.edu/main/facultystaff/barshopfaculty/u231
We are recruiting a motivated postdoctoral fellow to join our new research group. We encourage applications from candidates who have recently completed, or will soon complete, their PhD. The successful applicant will undergo a training program to prepare for an academic career including experimental design and execution, preparing manuscripts, competing for external funding, and presenting data at national meetings. The applicant should be creative, passionate about science, and able to work both independently and collaboratively.
Review of applicants will start immediately and will continue until the position is filled. Only shortlisted candidates will be notified.
Please submit a single pdf file to firstname.lastname@example.org with the following:
1. Cover letter summarizing of why you are interested in the Frost laboratory and a short description of your first-author publications
3. Contact information for two referees
Mitochondrial dysfunction in aging-related metabolic diseases
A postdoctoral scholar position is available immediately at Barshop Aging Institute of University of Texas Health Science Center at San Antonio, a leading institute in aging research, to identify molecular mechanisms that links aging to the onset of aging-related metabolic diseases using molecular, cellular, metabolic, knockout mouse, and lipidomic approaches. The primary focus of the laboratory is on translational aspects of aging and aging-related diseases, including type 2 diabetes, obesity, diabetic complications, and cardiovascular diseases, with an overarching goal to develop novel treatments for these conditions. The laboratory pioneered the initiation identification and functional characterization of PERK kinase and several lipid metabolic enzymes, including the first cardiolipin remodeling enzyme which plays a key role in linking mitochondrial dysfunction to the onset of several aging-related diseases (Cell Metabolism, 12, 154-165; Proc Natl Acad Sci USA, 109(18):6975-80; Mol Cell Biol. 2013 Jul;33(13):2527-34). Required qualifications include a PhD degree in molecular biology, metabolic diseases, or mitochondrial biology with demonstrated productivity in biomedical research. Candidate must be fluent in English. Experience in working with mitochondrial biology and knockout mice are definitely a plus.
Qualified candidate should send a copy of resume and three names of references to Prof. Roger Shi at email@example.com. For more information of the research work of the laboratory, please visit http://www.barshop.uthscsa.edu/main/facultystaff/barshopfaculty/u226.
Dr. Ikeno's laboratory is studying the effects of oxidative stress on aging and age-related pathology, using unique animal models that overexpress or downregulate antioxidant enzymes, including thioredoxin and Cu/Zn SOD. Research projects include: (1) redox sensitive signaling with mice that overexpress thioredoxin 1 or 2; and (2) obesity/inflammation/oxidative damage/insulin signaling with Cu/ZnSOD transgenic rats or mice fed a high-fat diet; (3) anti-tumor actions of caloric restriction.
Experience in standard techniques of molecular and cellular biology is required. A strong research background in the area of oxidative stress and signaling is appreciated.
Please use the link provided to contact Dr. Ikeno for more information.