Director: Randy Strong, PhD
The San Antonio Nathan Shock Center was one of the original Shock Centers founded by the NIH National Institute on Aging in 1995. The Center is a national resource that provides a state-of-the-art scientific infrastructure and services used in the development and study of rodent models to address questions about the basic biological mechanisms of aging. The Center also promotes the scientific study of aging by sponsoring seminars, conferences, and pilot grant awards focused on the basic biology of aging.
Co-Director: Suzette Tardif, PhD
The Emerging Animal Models Core is a multi-institutional research core established to promote and facilitate basic aging research. It employs nontraditional, exceptionally informative, animal species to investigate cellular and molecular mechanisms that modulate the rate of aging. Participating institutions are the UT Health Science Center at San Antonio (UTHSCSA), the University of Texas at San Antonio (UTSA), and the Texas Biomedical Research Institute (TBRI).
Co-director: James Nelson, PhD
The Aging Interventions Testing Program (ITP) at San Antonio is funded by the Biology of Aging Program of the National Institute on Aging (NIA) to evaluate treatment strategies likely to prevent or delay adverse age-dependent changes in cells and tissues, and to diminish the burden of disease in old age. Interventions considered for the program include, but are not limited to pharmaceuticals, nutraceuticals, dietary supplements, plant extracts, hormones, chelators, and redox agents.
Director: Merry L. Lindsey, PhD
The Cardiovascular Proteomics Center at San Antonio is funded by the National Heart, Lung, and Blood Institute to develop novel proteomic technologies to identify predictive markers of adverse remodeling of the left ventricle following myocardial infarction with a focus on extracellular matrix fragment generation as a key initiating event. Click here for link to video
The Marmoset Aging Center has established a specific-pathogen free, barrier-maintained colony of marmosets -- a unique primate model for the study of aging and age-related disease. The Center is the only facility in the world that maintains marmosets under barrier conditions, to promote excellent health and produce large numbers of aged animals for research.
The Naked Mole-Rat Center seeks to gain a better understanding of the cellular and molecular mechanisms that the longest-lived rodent, the naked mole-rat (NMR) uses to thwart the aging process and maintain cancer-free good health well into their third decade of life. In particular, the Center is currently using genomic and metabolomics approaches to address the underlying mechanisms that facilitate the maintenance of protein stability and genomic integrity in rodents of disparate longevity.
Dr. Buffenstein's colony of NMRs is not only the largest in the United States, but also contains the longest-lived of these animals, ages reaching older than 32 years.
Attention scientists: Click here should you have an interest in obtaining NMR tissue for your research project.
Core Co-leader: Alfred Fisher, PhD
The Bioanalytical Pharmacology Core seeks to provide research services related to the basic biology of aging at the UTHSCSA and other institutions in the San Antonio community. The services available include development of validated bioanalytical assays for drug interventions, pharmaceutics (development of effective dosage forms such as lab chow, injectables, etc), pharmacokinetics (drug availability in blood and tissues), and pharmacodynamics (drug effectiveness at the target of action).