Location: Barshop Institute 1000.2


Sam and Ann Barshop Insititute for Longevity and Aging Studies

Nicolas Musi, MD

Professor of Medicine
Director, Sam and Ann Barshop Institute for Longevity and Aging Studies
Director, Center for Healthy Aging
Director, San Antonio Claude D. Pepper Older Americans Independence Center
Associate Director for Research Programs, San Antonio Geriatric Research, Education, and Clinical Center (GRECC)

Personal Statement:

I am a physician-scientist and received clinical training in Internal Medicine at the University of Miami-Jackson Memorial Medical Center. I then completed a clinical and research fellowship in Endocrinology and Metabolism at the Joslin Diabetes Center of Harvard Medical School in 2001, after which I joined the Harvard faculty. I was recruited to the University of Texas Health Science Center (UTHSCSA) in 2003 and currently I am a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Sam and Ann Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and Associate Director for Research Programs for the San Antonio Geriatric Research, Education and Clinical Center.

I am an active educator and research mentor, and supervise clinical and research fellows, residents and graduate students. In this role, I function as Director of a T32 Training Grant on the Biology of Aging.


Year Degree Discipline Institution
1995 MD Medicine (Magna Cum Laude) Universidad Anahuac
Mexico City , Mexico
1996 Internship Internal Medicine University of Miami-Jackson Memorial Medical Center
Miami , FL
1998 Residency Internal Medicine University of Miami-Jackson Memorial Medical Center
Miami , FL
2001 Postdoctoral Fellowship Endocrinology and Metabolism Joslin Diabetes Center-Beth Israel Deaconnes Med Ct and Harvard Medical School
Boston , MA


My research expertise is in aging, insulin resistance and exercise physiology. My research program in metabolic/endocrine gerontology, is devoted to exploring the effects that aging has on numerous metabolic and cellular processes, and relevant to the patho-genesis of age-related diseases such as diabetes, obesity, and sarcopenia. My main clinical interests are (i) pathogenesis, prevention and treatment of diabetes in the elderly; (ii) molecular mechanisms underlying sarcopenia of aging; and (iii) effects of exercise on glucose and lipid metabolism at the whole-body and cellular levels. We conduct our research in human subjects, rodents, and cell cultures.

Exercise Physiology – We are interested in elucidating the molecular mechanism by which contractile activity and exercise improve physical performance and whole-body metabolism in the context of aging and diabetes. Ongoing studies are examining the role of the AMPK-PGC1 and the TLR4-NFkB pathways on the adaptations to exercise training.

Insulin Resistance – We aim to understand the molecular biology of insulin action in insulin resistant conditions. Techniques include: – Glucose kinetic studies in human subjects using the insulin clamp technique – Muscle biopsies in humans under hyperinsulinemic conditions and after exercise – Insulin sensitivity in rodents using the clamp technique and isolated muscle preparation – Primary human muscle cultures and co-cultures with adipocytes and inflammatory cells (monocytes, etc). – Methods for signaling studies include real-time PCR, kinase activity assays, Western blotting, siRNA, EMSA – Assays of mitochondrial function, including ATP production, oxygen consumption, membrane potential, and ROS generation.

Metabolism, Diabetes, Aging – We aim to delineate the effect of normal aging on the molecular pathways that control metabolism. Also, we work to elucidate the molecular alterations that increase the risk of metabolic disorders and disability relevant to aging, including diabetes, obesity and sarcopenia. We perform our research utilizing cell cultures and animal (rodent) models, and also conduct investigations in human subjects.