Barshop Institute
Category
November 12, 2018
Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila Cornelison GL, Levy SA, Jenson T, Frost B Aging Cell. 2018 Nov 9:e12847. doi: 10.1111/acel.12847. [Epub ahead of print] Abstract: The nucleus is a spherical dual-membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and […]
October 26, 2018
Marmoset as a model to study kidney changes associated with aging. Lee HJ, Gonzalez O, Dick EJ Jr, Donati A, Feliers D, Goutam Ghosh C, Ross C, Venkatachalam M, Tardif SD, Kasinath BS J Gerontol A Biol Sci Med Sci. 2018 Oct 13. doi: 10.1093/gerona/gly237. [Epub ahead of print] DOI: 10.1093/gerona/gly237 Abstract: We evaluated whether […]
October 26, 2018
Hydrogen sulfide ameliorates aging-associated changes in the kidney. Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG2, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS Geroscience. 2018 Apr;40(2):163-176. doi: 10.1007/s11357-018-0018-y. Epub 2018 May 1. PMCID: PMC5964063 Abstract: Aging is associated with replacement of normal kidney parenchyma by fibrosis. […]
August 25, 2018
DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher […]
August 25, 2018
Tau protein aggregation is associated with cellular senescence in the brain. Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME Aging Cell. 2018 Aug 20:e12840. doi: 10.1111/acel.12840. [Epub ahead of print] Abstract: Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer’s disease (AD), progressive supranuclear […]
August 25, 2018
Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice. Cunningham GM, Flores LC, Roman MG, Cheng C, Dube S, Allen C, Valentine JM, Hubbard GB, Bai Y, Saunders TL, Ikeno Y Geroscience. 2018 Aug 18. doi: 10.1007/s11357-018-0039-6. [Epub ahead of print] Abstract: To investigate the role […]
August 25, 2018
Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H693-H703. doi: 10.1152/ajpheart.00570.2017. Epub 2017 Dec 22. Abstract: An intact blood-brain barrier (BBB) limits […]
August 24, 2018
“Just because you are getting older doesn’t mean you have to deal with problems related to old age. Some of the world’s leading research on how to fight the consequences of aging is happening here in San Antonio at UT Health’s Barshop Institute for Longevity and Aging Studies. What have researchers and scientists discovered about treating […]
August 23, 2018
Congratulations to Dr. Bess Frost on her new publication in Nature Neuroscience, “Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies.” The Frost laboratory studies fundamental processes in cell biology that drive neurodegeneration and employs a multi-system approach to rapidly identify, test, and validate hypotheses. The study, which was spearheaded […]