Current Clinical Trials in Aging Research
Studies Currently Recruiting
Frailty Prevention
The overall goal of this project is to determine whether metformin treatment prevents or reduces frailty in older adults who have pre-diabetes.
STARR
The purpose of the South Texas Aging Registry and Repository (STARR) is to collect health information, blood and specimens to store for future research purposes. We want to learn more about how to improve the health and quality of life of older adults. We are also working to learn how genes affect the way a person ages or how aging influences genes and the cells they affect.
Exercise Science/MoTrPAC
You know that exercise is good for your health, but have you ever wondered why? We’re looking for men and women who are 18 years of age and older to participate in our MoTrPAC research study.
Alzheimer’s Study (ART-AD)
Have you or a loved one been diagnosed with early Alzheimer’s disease? This study may provide some help for you and others in the future by evaluating if a medication will effectively prevent decline and loss of function in the nervous system.
SGLT2i
Looking for participants who are 60 and older, overweight, and have borderline diabetes. We want to evaluate the effect of the FDA approved medication dapagliflozin on the reduction of cellular damage, pro-inflammatory cells of aging and other known markers of biological aging.
PREVENTABLE
The purpose of this study is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability or heart disease.
BESTOW
This study aims to gather input from women aged 60 and over who are currently experiencing binge eating. We are particularly interested in how we can modify treatments to better suit the needs and lifestyles of women over 60.
Topical RAPA
Help us find out if using RAPA ointment can slow down the aging of skin cells.
Alzheimer’s Study (REACH Clinical Trial)
This trial will evaluate the use of Rapamycin to slow progression of amnestic mild cognitive impairment and early-stage Alzheimer’s.
THRIVE
To test whether creatine supplements can accelerate improvements in strength and endurance associated with exercise in breast cancer survivors who recently completed chemotherapy.
Rapa-CV Substudy E
This study is looking for adults between the ages of 70-95 to help find out what effects Rapamycin has on heart function, heart muscle stiffening, and blood vessels.
Metformin in Alzheimer’s dementia Prevention (MAP) Study
Research study looking at whether metformin can help prevent memory decline for people with mild memory concerns.
Coming Soon
- Growth Hormone Replacement Therapy in Veterans with mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD): The GRIT Study
- Single nuclei RNA-seq to map adipose cellular populations and senescent cells in older subjects (SenNet KAPP)
- Targeting Aging with Metformin (TAME)
Studies Closed to Enrollment
- Targeting Pro-Inflammatory Cells in Idiopathic Pulmonary Fibrosis: a Human Trial
- The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition
- Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim1)
- Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2)
- The Physiological Effects of Intranasal Oxytocin on Sarcopenic Obesity (INOSO)
- Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly
- Healthy Weight Intervention
- Effect of Stress Busting Program on Caregivers’ Quality of Life, Immunology/Stress Biomarkers and Cellular Aging
- Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer’s Disease (MB2)
- Effect of Proton Pump Inhibitors on Gut Microbiota and Systemic Inflammation in Older Adults
- Aspirin in Reducing Events in the Elderly Extension
- Effects of topical Rapamycin Ointment
- Effect of Behavioral Lifestyle Intervention on Frailty in Older Adults with Diabetes: A Pilot Study (Behave Study)
- A Double-blind, Placebo Controlled, Randomized INTerventional Clinical Trial (SARA-INT Study)
- Impact of Metformin on Immunity (Immune/Met Study)
- Cognition, Age and Rapamycin Effectiveness-Downregulation of the mTor Pathway (CARPE DIEM Study)