Topical RAPA

Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock

Purpose of this Study

The purpose of this study is to find out if using RAPA ointment can slow down the aging of skin cells. The study will also help analyze the study ointment’s effect on reversing inflammatory changes or immune system responses thought to be associated with aging. In summary, this study will help determine what effects, good and/or bad, the RAPA ointment has on people who use it. The RAPA ointment will be applied topically to one of the participant’s forearms and matching placebo on the opposite forearm for a total of 6 months.

You may qualify if:

  • Are aged between 65-95 years old
  • Are in relatively good general health
  • Have no known allergy to study medication (8% sirolimus/rapamycin/RAPA ointment)

You may NOT qualify if:

  • Are a smoker
  • Have diabetes
  • Have a history of skin ulcers or poor wound healing, or keloid formers
  • Have a history of liver failure

Duration of the Study:

The study involves 8 visits (2 visits in the clinic and 6 visits at your home/phone) over the period of approximately 7 months.

Study Procedures:

  • Medical History
  • Physical exam
  • Electrocardiogram (EKG)
  • Blood tests
  • Cognitive screening

Study Location:

Audie L. Murphy Memorial Veterans’ Hospital
Bartter Clinical Research Unit, 7th floor
7400 Merton Minter Blvd.
San Antonio, TX 78229


Up to $350

Principal Investigator:

Ellen Kraig, PhD

Co-Principal Investigator:

Dean L. Kellogg, Jr., MD, PhD

Contact Us

For more information or to volunteer in a study:

  • Call (210) 834-7819
  • If you prefer that we contact you, please fill out the form below.
Contact Us Clinical