Topical RAPA

Can rapamycin (RAPA) slow down aging?

*This study is now fully enrolled and no additional subjects are currently being recruited.

The purpose of this study is to find out if using RAPA ointment can slow down the aging of skin cells. The study will also help analyze the study ointment’s effect on reversing inflammatory changes or immune system responses thought to be associated with aging. In summary, this study will help determine what effects the RAPA ointment has on people who use it. The RAPA ointment will be applied topically to one of the participant’s forearms and matching placebo on the opposite forearm for a total of 6 months.

• Are between the ages of 65 and 95
• Are in relatively good general health and non-smoker
• Do not have diabetes
• Are fully vaccinated against COVID-19
• Are willing to attend 8 visits in a 7-month period
  (2 in clinic and 6 visits at your home*)
• Live within 20 miles of the UTHSA to facilitate home visits*
• Have no known allergy to study medications
  (8% sirolimus/rapamycin/RAPA ointment)

• Are a smoker
• Have diabetes
• Have a history of skin ulcers or poor wound healing, or keloid formers
• Have a history of liver failure

The study involves 8 visits (2 visits in the clinic and 6 visits at your home/phone*) over the period of approximately 7 months.

• Medical History
• Physical exam
• Electrocardiogram (EKG)
• Blood tests
• Cognitive screening

UT Health San Antonio and Home Visits*

*Home visits may take place at an alternate private site if mutually convenient and within 20 miles of UTHSA.

Up to $350