Frailty Prevention

Metformin for Preventing Frailty in High Risk Older Adults

(Hablamos español)

Purpose of this Study

This project’s overall goal is to determine whether metformin treatment prevents or reduces frailty in older adults who have pre-diabetes.

You may qualify if:

  • Age 65 and older
  • A non-smoker
  • Borderline diabetes
  • Living independently

You may NOT qualify if:

  • Live in a nursing home or assisted living facility.
  • Have diabetes
  • Have a chronic or disabling disease
  • You are using medications for diabetes.

Duration of the Study:

This is a two-year study with approximately 14 study visits. These visits will occur every 3-6 months.

Study Procedures:

Study Location:

South Texas Veterans Health Care System
Audie L. Murphy Memorial Veterans Hospital
7400 Merton Minter Blvd.
San Antonio, TX 78229

All visits are conducted on the 7th floor at the Bartter Clinical Research Unit.


Up to $1,700 is offered for the completion of this study.

Principal Investigator:

Sara Espinoza, MD, MSc

Contact Us

For more information or to volunteer in a study:

  • Call (210) 450-0020
  • If you prefer that we contact you, please fill out the form below.
Contact Us Clinical