Frailty Prevention

Metformin for Preventing Frailty in High Risk Older Adults

(This study is now fully enrolled and no additional subjects are currently being recruited)

Purpose of this Study

This project’s overall goal is to determine whether metformin treatment prevents or reduces frailty in older adults who have pre-diabetes.

You may qualify if:

• Age 65 and older
• A non-smoker
• Living independently

You may NOT qualify if:

• Live in a nursing home or assisted living facility.
• Have diabetes
• Have a chronic or disabling disease
• You are using medications for diabetes.

Duration of the Study:

This is a two-year study with approximately 14 study visits. These visits will occur every 3-6 months.

Study Procedures:

• Medical
• Physical examination/assessment
• Blood tests
• Oral Glucose Tolerance Test
• Body composition (DEXA)
• Urine and stool collection
• Muscle specimen (click for more details)

Study Locations:

South Texas Veterans Health Care System
Audie L. Murphy Memorial Veterans Hospital
7400 Merton Minter Blvd.
San Antonio, TX 78229

UT Health San Antonio
Sam and Ann Barshop Institute for Longevity and Aging Studies
4939 Charles Katz Dr.
San Antonio, TX 78229

Compensation:

Compensation offered for the completion of this study.

Principal Investigator:

Sara Espinoza, MD, MSc

Contact Us

For more information or to volunteer in a study:

• Call (210) 450-0020
• If you prefer that we contact you, please fill out the form below.