Sulfatide Deficiency, an Early Alzheimer’s Lipidomic Signature, Causes Brain Ventricular Enlargement in the Absence of Classical Neuropathological Hallmarks
January 17, 2023
Sulfatide Deficiency, an Early Alzheimer’s Lipidomic Signature, Causes Brain Ventricular Enlargement in the Absence of Classical Neuropathological Hallmarks Juan Pablo Palavicini, Lin Ding, Meixia Pan, Shulan Qiu, Hu Wang, Qiang Shen, Jeffrey L. Dupree, and Xianlin Han International Journal of Molecular Sciences, 2023, 24(1), 233; https://doi.org/10.3390/ijms24010233 Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease characterized […]
Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment
September 21, 2021
Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment. Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree & Xianlin Han. Molecular Neurodegeneration, 2021 Sep 15;16(1):64. doi: 10.1186/s13024-021-00488-7. PMID: […]
Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes
November 24, 2020
Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. Juan P Palavicini, Juan Chen, Chunyan Wang, Jianing Wang, Chao Qin, Eric Baeuerle, Xinming Wang, Jung A Woo, David E Kang, Nicolas Musi, Jeffrey L Dupree, Xianlin Han. JCI Insight. 2020 Nov 5;5(21):137286. doi: 10.1172/jci.insight.137286. Abstract: Diabetic neuropathy is a major complication of […]
APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain.
January 24, 2020
APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain. Lefterov I, Wolfe CM, Fitz NF, Nam KN, Letronne F, Biedrzycki RJ, Kofler J, Han X, Wang J, Schug J, Koldamova R Alzheimers Res Ther. 2019 Dec 30;11(1):113. doi: 10.1186/s13195-019-0558-0. Abstract: BACKGROUND: The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed […]
Altered bile acid profile associates with cognitive impairment in Alzheimer’s disease-An emerging role for gut microbiome.
October 21, 2019
Altered bile acid profile associates with cognitive impairment in Alzheimer’s disease-An emerging role for gut microbiome. MahmoudianDehkordi S, Arnold M, Nho K, Ahmad S, Jia W, Xie G, Louie G, Kueider-Paisley A, Moseley MA, Thompson JW, St John Williams L, Tenenbaum JD, Blach C, Baillie R, Han X, Bhattacharyya S, Toledo JB, Schafferer S, Klein […]
Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors.
October 21, 2019
Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors. Gao CZ, Dong W, Cui ZW, Yuan Q, Hu XM, Wu QM, Han X, Xu Y, Min ZL Journal of Enzyme Inhibition and Medicinal Chemistry. 2019 Dec;34(1):150-162. doi: 10.1080/14756366.2018.1530224. Abstract: A series of new Olaparib derivatives was […]
Altered bile acid profile in mild cognitive impairment and Alzheimer’s disease: Relationship to neuroimaging and CSF biomarkers.
October 21, 2019
Altered bile acid profile in mild cognitive impairment and Alzheimer’s disease: Relationship to neuroimaging and CSF biomarkers. Nho K, Kueider-Paisley A, MahmoudianDehkordi S, Arnold M, Risacher SL, Louie G, Blach C, Baillie R, Han X, Kastenmüller G, Jia W, Xie G, Ahmad S, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy […]
Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.
October 21, 2019
Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis. Puchalska P, Martin SE, Huang X, Lengfeld JE, Daniel B, Graham MJ, Han X, Nagy L, Patti GJ, Crawford PA Cell Metabolism. 2019 Feb 5;29(2):383-398.e7. doi: 10.1016/j.cmet.2018.10.015. Epub 2018 Nov 15. Abstract: Metabolic plasticity has been linked to polarized macrophage function, but mechanisms connecting specific fuels to tissue […]
Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc1 complex function.
October 21, 2019
Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc1 complex function. Calzada E, Avery E, Sam PN, Modak A, Wang C, McCaffery JM, Han X, Alder NN, Claypool SM Nature Communications. 2019 Mar 29;10(1):1432. doi: 10.1038/s41467-019-09425-1. Abstract: Of the four separate PE biosynthetic pathways in eukaryotes, one occurs in the mitochondrial […]
Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis.
October 21, 2019
Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis. Zhang X, Zhang J, Sun H, Liu X, Zheng Y, Xu D, Wang J, Jia D, Han X, Liu F, Nie J, Shi Y Cellular and Molecular Gastroenterology and Hepatology. 2019;7(4):763-781. doi: 10.1016/j.jcmgh.2019.02.002. Epub 2019 Mar 1. Abstract: BACKGROUND & AIMS: Obesity promotes the development […]