Insulin Resistance in Skeletal Muscle Selectively Protects the Heart in Response to Metabolic Stress
October 3, 2022
Insulin Resistance in Skeletal Muscle Selectively Protects the Heart in Response to Metabolic Stress Dandan Jia, Jun Zhang, Xueling Liu, John-Paul Andersen, Zhenjun Tian, Jia Nie, Yuguang Shi Diabetes. 2021 Oct;70(10):2333-2343. doi: 10.2337/db20-1212. Epub 2021 Jul 8. Abstract: Obesity and type 2 diabetes mellitus (T2DM) are the leading causes of cardiovascular morbidity and mortality. Although […]
Proximal tubular epithelial insulin receptor mediates high fat diet-induced kidney injury
March 29, 2022
Proximal tubular epithelial insulin receptor mediates high fat diet-induced kidney injury Hak Joo Lee, Meenalakshmi M Mariappan, Luke Norton, Terry Bakewell, Denis Feliers, Sae Byeol Oh, Andrew Donati, Cherubina S Rubannelsonkumar, Manjeri A Venkatachalam, Stephen E Harris, Isabelle Rubera, Michel Tauc, Goutam Ghosh Choudhury, C Ronald Kahn, Kumar Sharma, Ralph A DeFronzo, Balakuntalam S Kasinath […]
mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer’s Disease
March 29, 2022
mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer’s Disease Candice E Van Skike, Stacy A Hussong, Stephen F Hernandez, Andy Q Banh, Nicholas DeRosa, Veronica Galvan Journal of Neuroscience. 2021 May 12;41(19):4305-4320. doi: 10.1523/JNEUROSCI.2144-20.2021. Abstract: Vascular dysfunction is a universal feature of aging and decreased cerebral blood flow has […]
Age and sex modify cellular proliferation responses to oxidative stress and glucocorticoid challenges in baboon cells
March 29, 2022
Age and sex modify cellular proliferation responses to oxidative stress and glucocorticoid challenges in baboon cells Daniel A Adekunbi, Cun Li, Peter W Nathanielsz, Adam B Salmon Geroscience. 2021 Aug;43(4):2067-2085. doi: 10.1007/s11357-021-00395-1. Epub 2021 Jun 5. Abstract: Aging is associated with progressive loss of cellular homeostasis resulting from intrinsic and extrinsic challenges. Lack of a […]
Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice
March 29, 2022
Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice Jonathan D Dorigatti, Kevin M Thyne, Brett C Ginsburg, Adam B Salmon Geroscience. 2021 Jun;43(3):1497-1511. doi: 10.1007/s11357-021-00372-8. Epub 2021 Apr 23. Abstract: AMP-activated protein kinase (AMPK) is a central regulator of both lifespan and health across multiple model organisms. β-Guanidinopropionic acid (GPA) […]
Cardiolipin remodeling by ALCAT1 links hypoxia to coronary artery disease by promoting mitochondrial dysfunction
March 29, 2022
Cardiolipin remodeling by ALCAT1 links hypoxia to coronary artery disease by promoting mitochondrial dysfunction Dandan Jia, Jun Zhang, Jia Nie, John-Paul Andersen, Samantha Rendon, Yue Zheng, Xueling Liu, Zhenjun Tian, Yuguang Shi Molecular Therapy. 2021 Dec 1;29(12):3498-3511. doi: 10.1016/j.ymthe.2021.06.007. Epub 2021 Jun 8. Abstract: Cardiolipin is a mitochondrial signature phospholipid that plays a pivotal role […]
LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance
January 7, 2022
LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance Sijia He, Jiyoon Ryu, Juanhong Liu, Hairong Luo, Ying Lv, Paul R Langlais, Jie Wen, Feng Dong, Zhe Sun, Wenjuan Xia, Jane L Lynch, Ravindranath Duggirala, Bruce J Nicholson, Mengwei Zang, Yuguang Shi, Fang Zhang, Feng Liu, Juli Bai, Lily Q Dong. J Clin […]
The Insulin-Sensitizer Pioglitazone Remodels Adipose Tissue Phospholipids in Humans
December 13, 2021
The Insulin-Sensitizer Pioglitazone Remodels Adipose Tissue Phospholipids in Humans Juan P. Palavicini, Alberto Chavez-Velazquez, Marcel Fourcaudot, Devjit Tripathy, Meixia Pan, Luke Norton, Ralph A. DeFronzo and Christopher E. Shannon Frontiers in Physiology, 02 December 2021 | DOI: doi.org/10.3389/fphys.2021.784391 Abstract: The insulin-sensitizer pioglitazone exerts its cardiometabolic benefits in type 2 diabetes (T2D) through a redistribution of […]
Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system
October 21, 2021
Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system. Paulino Ramirez, Gabrielle Zuniga, Wenyan Sun, Adrian Beckmann, Elizabeth Ochoa, Sarah L. DeVos, Bradley Hyman, Gabriel Chiu, Ethan R. Roy, Wei Cao, Miranda Orr, Virginie Buggia-Prevot, William J. Ray, and Bess Frost. Progress in Neurobiology. Available online 17 October 2021. https://doi.org/10.1016/j.pneurobio.2021.102181. […]
The treatment of neurogenic lower urinary tract dysfunction in persons with spinal cord injury: An open label, pilot study of anticholinergic agent vs. mirabegron to evaluate cognitive impact and efficacy
September 22, 2021
The treatment of neurogenic lower urinary tract dysfunction in persons with spinal cord injury: An open label, pilot study of anticholinergic agent vs. mirabegron to evaluate cognitive impact and efficacy. Michelle Trbovich, Terry Romo, Marsha Polk, Wouter Koek, Che Kelly, Sharon Stowe, Stephen Kraus, Dean Kellogg. Spinal Cord Series and Cases. 2021 Jun 10;7(1):50. doi: […]