Xianlin Han, PhD
Professor
Personal Statement:
I am an internationally-renowned investigator in the fields of lipidomics, lipid metabolism, and lipid biochemistry. I have developed expertise in broad areas of research, such as diabetes, neuroscience, and metabolic biochemistry. The mass spectrometric techniques for lipidomics developed in our group, collectively termed “multi-dimensional mass spectrometry-based shotgun lipidomics” with unparalleled high sensitivity and comprehensive coverage, have been widely used to identify altered lipid metabolism, trafficking, and homeostasis, and biomarkers under patho(physio)logical conditions. The current interests of my laboratory research focus on diabetic neuropathy, mitochondrial dysfunction in diabetic hearts, and Alzheimer’s disease. I have the expertise, leadership, training, and motivation necessary to conduct these research projects. As an investigator or co-investigator on over twenty previous NIH-funded grants, I have successfully administered the projects and produced several peer-reviewed publications from each project, resulting in a total of over 250 peer-reviewed publications. It is gratifying that my contribution has received over 21,000 citations (over half are since 2013) with an h-index of 72 (Google Scholar, 2018).
Education
| Year | Degree | Discipline | Institution |
| 1982 | BS | Chemistry | Zhejiang University P.R. , China |
| 1985 | MS | Chemical Thermodynamics | Zhejiang University P.R. , China |
| 1987 | MA | Physical Chemistry | Washington University St. Louis , MO |
| 1990 | Internship | Washington University St. Louis , MO |
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| 1990 | PhD | Biophysical and Bioanalytical Chemistry | Washington University St. Louis , MO |
Research
Our research focuses on identification of the molecular and biochemical mechanisms underlying alterations in lipid metabolism, signaling, and homeostasis that occur under patho(physio)logical conditions such as aging, Alzheimer’s disease (AD), diabetes, and cancer by lipidomics. Lipid metabolism spans a highly elaborate system comprised of numerous classes and subclasses, and hundreds of thousands of species that make up the cellular lipidomes. A large number of pathways and networks which are highly dynamic and interwoven are involved in lipid metabolism. Identifying the mechanisms underpinning alterations in lipid metabolism, signaling, and homeostasis that occur under patho(physio)logical conditions could unravel disease pathogenesis, uncover drug targets for treatment, and identify biomarkers for early diagnosis and prognosis of the diseases. Lipidomics, which facilitates large-scale analysis of cellular lipidomes based on the principles and techniques of analytical chemistry, could allow us to comprehensively and effectively determine alterations in lipid metabolism, signaling, and homeostasis under the conditions.
Our laboratory is one of the world-leading research groups on lipidomics. We have developed an enabling technology with in-house software programs termed “multi-dimensional mass spectrometry-based shotgun lipidomics (MDMS-SL)”, initiated in the early 1990s and still under constant evolution. The MDMS-SL technology provides modular, robust, and label-free quantification of lipids. At its current stage, the technology enables us to identify and quantify over 50 lipid classes, over 95% of lipid mass content, and thousands of individual lipid molecular species from limited amounts of biological samples in an accurate (>90% reproducibility) and relatively high throughput fashion. By using lipidomics, we have developed a few research projects (supported with NIH funds and other sources) including AD and diabetes-associated dementia, as well as multiple minor translational research projects such as anesthetics-induced neurotoxicity and cancer biomarkers. By using our enabling lipidomics technology, we have also established numerous (inter)national collaborations on a variety of research areas.
Awards & Accomplishments
| 2003 | Memory Ride Prize | ||
| 2017-Present | Methodist Hospital Foundation Chair in Aging Studies and Research, University of Texas Health Science Center at San Antonio | ||
| 2018 | University of Texas System STARs Award | ||
| Guest Professors | Changchun Institute of Applied Chemistry, Chinese Academy of Sciences; Soochow University; and Oil Crop Research Institute, Chinese Academy of Agricultural Sciences | ||
Affiliations
Barshop Institute for Longevity and Aging Studies
Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases
Department of Medicine, Division of Diabetes
Department of Biochemistry and Structural Biology
University of Texas Health Science Center at San Antonio
Lab Members
| Dr. Chunyan Wang | Senior Post-Doctoral Fellow | ||
 Dr. Juan Pablo Palavicini |
Senior Post-Doctoral Fellow | ||
 Dr. Jianing Wang |
Post-Doctoral Fellow | ||
| Dr. Shulan Qiu | Post-Doctoral Fellow | ||
 Mr. Charles Chao Qin |
Research Associate | ||
| Prof. Juan Chen | Visiting Scholar | ||
| Prof. Zhenli Min | Visiting Scholar | ||
News
Dr. Han is the University of Texas System STARs Awardee.
Drs. Han and Seshadri received ~$3.5 million grant award from the NIH National Institute on Aging to unravel the mechanisms by which APOE2 confers neuroprotection against aging and AD.
Publications
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Analytical challenges of shotgun lipidomics at different resolution of measurements. |
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Can Oral Health and Oral-derived Biospecimens Predict Progression of Dementia? |
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Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. |
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Novel strategies for enhancing shotgun lipidomics for comprehensive analysis of cellular lipidomes. |
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Tutorial on lipidomics. |
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Strategies to Improve/Eliminate the Limitations in Shotgun Lipidomics. |
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MondoA drives muscle lipid accumulation and insulin resistance. |
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Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers. |
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Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration. |
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AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice. |
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Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis. |
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Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc1 complex function. |
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Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis. |
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Altered bile acid profile in mild cognitive impairment and Alzheimer’s disease: Relationship to neuroimaging and CSF biomarkers. |
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Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors. |
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Altered bile acid profile associates with cognitive impairment in Alzheimer’s disease-An emerging role for gut microbiome. |
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Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure. |
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Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome. |
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Enhanced coverage of lipid analysis and imaging by matrix-assisted laser desorption/ionization mass spectrometry via a strategy with an optimized mixture of matrices. |
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Strategy for Quantitative Analysis of Isomeric Bis(monoacylglycero)phosphate and Phosphatidylglycerol Species by Shotgun Lipidomics after One-Step Methylation. |