Contact

Location: MED 334.5D

Department

Cellular and Integrative Physiology

Peter J. Hornsby, PhD

Professor

Personal Statement:

My research interests are in regenerative medicine, as described below. I also serve as the Co-Director of the San Antonio Nathan Shock Center and as Co-Leader of the Research Career Development Core of the San Antonio Older Americans Independence Center (Pepper Center). My teaching activities focus on gastrointestinal physiology, both within the Medical School and the Graduate School.


Education

Year Degree Discipline Institution
1971 BA (Honors) Animal Physiology University of Oxford
Oxford, England, UK
1974 PhD Cell Biology University of London Institute of Cancer Research
London, England, UK
Postdoctoral Fellowship Biochemistry University of California San Diego, School of Medicine
San Diego, CA

Research

Regenerative Medicine – Stem Cell Delivery. Our research focuses on modes of stem cell delivery to exert a therapeutic effect in age-related diseases. Most recently the lab’s research has concerned intranasal delivery of mesenchymal stem cells to the brain.

“Human mesenchymal stem cells crossing the cribriform plate into the brain in a mouse. Human stem cells were labeled with quantum dots (red) and administered intranasally. Two hours later they are seen crossing the cribriform plate in this image (arrows). In (b) nuclei have been stained green. (c) is an overlay of (a) and (b). cp = cribriform plate; fo = fila olfactoria; lp = lamina propria; oe = olfactory epithelium; onl = olfactory nerve layer”

Affiliations

American Aging Association

Publications

The route by which intranasally delivered stem cells enter the central nervous system.
Galeano C, Qiu Z, Mishra A, Farnsworth SL, Hemmi JJ, Moreira A, Edenhoffer P, Hornsby, PJ
Cell Transplantation. 2018 Mar;27(3):501-514. doi: 10.1177/0963689718754561. Epub 2018 May 14.
PMCID: PMC6038044

Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: A systematic review and meta-analysis of preclinical studies.
Archambault J, Moreira A, McDaniel D, Winter L, Sun L, Hornsby PJ
PLoS One. 2017 Dec 19;12(12):e0189895. doi: 10.1371/journal.pone.0189895. eCollection 2017.
PMCID: PMC5736208

Upcycling umbilical cords: bridging regenerative medicine with neonatology.
Moreira A, Alayli Y, Balgi S, Winter C, Kahlenberg S, Mustafa S, Hornsby PJ
Journal of Maternal-Fetal and Neonatal Medicine. 2017 Nov 27:1-10. doi: 10.1080/14767058.2017.1405387. [Epub ahead of print]
PMID: 29132234

Therapeutic potential of mesenchymal stem cells for diabetes.
Moreira A, Kahlenberg S, Hornsby PJ
Journal of Molecular Endocrinology. 2017 Oct;59(3):R109-R120. doi: 10.1530/JME-17-0117. Epub 2017 Jul 24.
PMCID: PMC5570611

Overcoming barriers to reprogramming and differentiation in nonhuman primate induced pluripotent stem cells.
Hemmi JJ, Mishra A, Hornsby PJ
Primate Biology. 2017 Aug 18;4(2):153-162. doi: 10.5194/pb-4-153-2017.

Induced Pluripotent Stem Cells from Nonhuman Primates.
Mishra A, Qiu Z, Farnsworth SL, Hemmi JJ, Li M, Pickering AV, Hornsby PJ
Methods in Molecular Biology. 2016;1357:183-93. doi: 10.1007/7651_2014_159.
PMCID: PMC4483148

Marmoset induced pluripotent stem cells: Robust neural differentiation following pretreatment with dimethyl sulfoxide.
Qiu Z, Mishra A, Li M, Farnsworth SL, Guerra B, Lanford RE, Hornsby PJ
Stem Cell Research. 2015 Jul;15(1):141-50. doi: 10.1016/j.scr.2015.05.010. Epub 2015 May 27.
PMCID: PMC4516655