Location: MED 334.5D


Cellular and Integrative Physiology

Peter J. Hornsby, PhD


Personal Statement:

My research interests are in regenerative medicine, as described below. I also serve as the Co-Director of the San Antonio Nathan Shock Center and as Co-Leader of the Research Career Development Core of the San Antonio Older Americans Independence Center (Pepper Center). Recently, I co-edited the 9th edition of the Handbook of the Biology of Aging together with Dr. Nicolas Musi, director of the Barshop Institute.


1971BA (Honors)Animal PhysiologyUniversity of Oxford
Oxford, England, UK
1974PhDCell BiologyUniversity of London Institute of Cancer Research
London, England, UK
Postdoctoral FellowshipBiochemistryUniversity of California San Diego, School of Medicine
San Diego, CA


Regenerative Medicine – Stem Cell Delivery. Our research focuses on modes of stem cell delivery to exert a therapeutic effect in age-related diseases. Most recently the lab’s research has concerned intranasal delivery of mesenchymal stem cells to the brain.

“Human mesenchymal stem cells crossing the cribriform plate into the brain in a mouse. Human stem cells were labeled with quantum dots (red) and administered intranasally. Two hours later they are seen crossing the cribriform plate in this image (arrows). In (b) nuclei have been stained green. (c) is an overlay of (a) and (b). cp = cribriform plate; fo = fila olfactoria; lp = lamina propria; oe = olfactory epithelium; onl = olfactory nerve layer”


American Aging Association


1.Salmon, A. B., Nelson, J. F., Gelfond, J., Javors, M., Ginsburg, B., Lopez-Cruzan, M., Galvan, V., Fernandez, E., Musi, N., Ikeno, Y., Hubbard, G., Lechleiter, J., Hornsby, P. J., & Strong, R. (2021). San Antonio Nathan Shock Center: your one-stop shop for aging research. GeroScience, 43(5), 2105–2118.
2.Hornsby, P. J., 2021, Induced pluripotent stem cells from nonhuman primates. Advances in Stem Cell Biology vol 2, Birbrair, A., Academic Press, London, pp.45-57
3.Hornsby, P. J., 2021, The nature of aging and the geroscience hypothesis. Handbook of the Biology of Aging, 9th Ed., Musi, N.; Hornsby, P.J., Elsevier, London, pp.69-76
4.Guderyon, M. J., Chen, C., Bhattacharjee, A., Ge, G., Fernandez, R. A., Gelfond, J., Gorena, K. M., Cheng, C. J., Li, Y., Nelson, J. F., Strong, R. J., Hornsby, P. J., Clark, R. A., & Li, S. (2020). Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice. Aging cell, 19(3), e13110.
5.Moreira, A., Winter, C., Joy, J., Winter, L., Jones, M., Noronha, M., Porter, M., Quim, K., Corral, A., Alayli, Y., Seno, T., Mustafa, S., Hornsby, P., & Ahuja, S. (2020). Intranasal delivery of human umbilical cord Wharton's jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia. Stem cells translational medicine, 9(2), 221–234.
6.Farnsworth, S. L., Qiu, Z., Mishra, A., & Hornsby, P. J. (2019). Optimization of Differentiation of Nonhuman Primate Pluripotent Cells Using a Combinatorial Approach. Methods in molecular biology (Clifton, N.J.), 1919, 187–197.
7.Balgi-Agarwal, S., Winter, C., Corral, A., Mustafa, S. B., Hornsby, P., & Moreira, A. (2018). Comparison of Preterm and Term Wharton's Jelly-Derived Mesenchymal Stem Cell Properties in Different Oxygen Tensions. Cells, tissues, organs, 205(3), 137–150.
8.Galeano, C., Qiu, Z., Mishra, A., Farnsworth, S. L., Hemmi, J. J., Moreira, A., Edenhoffer, P., & Hornsby, P. J. (2018). The Route by Which Intranasally Delivered Stem Cells Enter the Central Nervous System. Cell transplantation, 27(3), 501–514.