Contact

Location: MED 334.5D

Department

Cellular and Integrative Physiology

Peter J. Hornsby, PhD

Professor

Personal Statement:

My research interests are in regenerative medicine, as described below. I also serve as the Co-Director of the San Antonio Nathan Shock Center and as Co-Leader of the Research Career Development Core of the San Antonio Older Americans Independence Center (Pepper Center). Recently, I co-edited the 9th edition of the Handbook of the Biology of Aging together with Dr. Nicolas Musi, director of the Barshop Institute.


Education

Year Degree Discipline Institution
1971 BA (Honors) Animal Physiology University of Oxford
Oxford, England, UK
1974 PhD Cell Biology University of London Institute of Cancer Research
London, England, UK
Postdoctoral Fellowship Biochemistry University of California San Diego, School of Medicine
San Diego, CA

Research

Regenerative Medicine – Stem Cell Delivery. Our research focuses on modes of stem cell delivery to exert a therapeutic effect in age-related diseases. Most recently the lab’s research has concerned intranasal delivery of mesenchymal stem cells to the brain.

“Human mesenchymal stem cells crossing the cribriform plate into the brain in a mouse. Human stem cells were labeled with quantum dots (red) and administered intranasally. Two hours later they are seen crossing the cribriform plate in this image (arrows). In (b) nuclei have been stained green. (c) is an overlay of (a) and (b). cp = cribriform plate; fo = fila olfactoria; lp = lamina propria; oe = olfactory epithelium; onl = olfactory nerve layer”

Affiliations

American Aging Association

Publications

Galeano, C.; Qiu, Z.; Mishra, A.; Farnsworth, S.L.; Hemmi, J.J.; Moreira, A.; Edenhoffer, P.; Hornsby, P.J., 2018, The route by which intranasally delivered stem cells enter the central nervous system. Cell Transpl. 27 501-514

Balgi-Agarwal, S.; Winter, C.; Corral, A.; Mustafa, S.B.; Hornsby, P.J.; Moreira, A., 2018, Comparison of preterm and term Wharton’s jelly-derived mesenchymal stem cell properties in differing oxygen tensions. Cells Tissue Organs 205 137-150

Farnsworth, S.L.; Qiu, Z.; Mishra, A.; Hornsby, P.J., 2019, Optimization of differentiation of nonhuman primate pluripotent cells using a combinatorial approach. Methods Mol. Biol. 1919 187-197

Moreira, A.; Winter, C.; Joy, J.; Winter, L.; Jones, M.; Noronha, M.; Porter, M.; Quim, K.; Corral, A.; Alayli, Y.; Seno, T.; Mustafa, S.; Hornsby, P.J.; Ahuja, S., 2019, Intranasal delivery of human umbilical cord Wharton’s jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia. Stem Cells Transl. Med. 9 221-234

Guderyon, M.J.; Chen, C.; Bhattacharjee, A.; Ge, G.; Fernandez, R.A.; Gelfond, J.A.L.; Gorena, K.M.; Cheng, C.J.; Li, Y.; Nelson, J.F.; Strong, R.J.; Hornsby, P.J.; Clark, R.A.; Li, S., 2020, Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice. Aging Cell 19 e13110-

Hornsby, P.J., 2021, The nature of aging and the geroscience hypothesis. Handbook of the Biology of Aging, 9th Ed., Musi, N.; Hornsby, P.J., Elsevier, London, pp.69-76

Hornsby, P.J., 2021, Induced pluripotent stem cells from nonhuman primates. Advances in Stem Cell Biology vol 2, Birbrair, A., Academic Press, London, pp.45-57