Location: Barshop Institute 1051



Yuji Ikeno, MD, PhD


Personal Statement:

Over the past 27 years, I have been directly responsible for the pathological analyses of all animals studied in multiple Program Projects and the San Antonio Nathan Shock Aging Center. In addition to pathological analyses of aging animals, I also have multiple research projects that seek the underlying mechanisms of aging. The primary goal of my research is to test whether changes in oxidative stress and redox status in the cell attenuate aging and age-related pathology, e.g., cancer, obesity, and type-2 diabetes, using unique animal models with altered levels of various antioxidant enzymes, e.g., thioredoxin transgenic/knockout mice, Cu/ZnSOD transgenic rats.


1987MDMedicineNagasaki University School of Medicine
Nagasaki , Japan
1993PhDMedicine/PathologyNagasaki University School of Medicine
Nagasaki , Japan


1.Lee, H. J., Donati, A., Feliers, D., Sun, Y., Ding, Y., Madesh, M., Salmon, A. B., Ikeno, Y., Ross, C., O'Connor, C. L., Ju, W., Bitzer, M., Chen, Y., Choudhury, G. G., Singh, B. B., Sharma, K., & Kasinath, B. S. (2021). Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury. Aging cell, 20(7), [e13407].
2.Duran-Ortiz, S., List, E. O., Ikeno, Y., Young, J., Basu, R., Bell, S., McHugh, T., Funk, K., Mathes, S., Qian, Y., Kulkarni, P., Yakar, S., Berryman, D. E., & Kopchick, J. J. (2021). Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan. Aging cell, 20(12), [e13506].
3.Cantwell, A. M., Singh, H., Platt, M., Yu, Y., Lin, Y. H., Ikeno, Y., Hubbard, G., Xiang, Y., Gonzalez-Juarbe, N., & Dube, P. H. (2021). Kinetic multi-omic analysis of responses to SARS-CoV-2 infection in a model of severe COVID-19. Journal of virology, 95(20), [e01010-21].
4.Salmon, A. B., Nelson, J. F., Gelfond, J. A. L., Javors, M., Ginsburg, B., Lopez-Cruzan, M., Galvan, V., Fernandez, E., Musi, N., Ikeno, Y., Hubbard, G., Lechleiter, J., Hornsby, P. J., & Strong, R. (2021). San Antonio Nathan Shock Center: your one-stop shop for aging research. GeroScience, 43(5), 2105-2118.
5.Poudel, S. B., Dixit, M., Yildirim, G., Cordoba-Chacon, J., Gahete, M. D., Yuji, I., Kirsch, T., Kineman, R. D., & Yakar, S. (2021). Sexual dimorphic impact of adult-onset somatopause on life span and age-induced osteoarthritis. Aging cell, 20(8), [e13427].
6.Jiang, Z., Bahr, T., Zhou, C., Jin, T., Chen, H., Song, S., Ikeno, Y., Tian, H., & Bai, Y. (2020). Diagnostic value of circulating cell-free mtDNA in patients with suspected thyroid cancer: ND4/ND1 ratio as a new potential plasma marker. Mitochondrion, 55, 145-153.
7.Camell, C. D., Günther, P., Lee, A., Goldberg, E. L., Spadaro, O., Youm, Y. H., Bartke, A., Hubbard, G. B., Ikeno, Y., Ruddle, N. H., Schultze, J., & Dixit, V. D. (2019). Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metabolism, 30(6), 1024-1039.e6.
8.Mitchell, S. J., Bernier, M., Mattison, J. A., Aon, M. A., Kaiser, T. A., Anson, R. M., Ikeno, Y., Anderson, R. M., Ingram, D. K., & de Cabo, R. (2019). Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories. Cell Metabolism, 29(1), 221-228.e3.
9.Habermehl, T. L., Parkinson, K. C., Hubbard, G. B., Ikeno, Y., Engelmeyer, J. I., Schumacher, B., & Mason, J. B. (2019). Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice. GeroScience, 41(1), 25-38.
10.Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., ... Jurk, D. (2019). Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metabolism, 29(5), 1061-1077.e8.
11.Mao, K., Quipildor, G. F., Tabrizian, T., Novaj, A., Guan, F., Walters, R. O., Delahaye, F., Hubbard, G. B., Ikeno, Y., Ejima, K., Li, P., Allison, D. B., Salimi-Moosavi, H., Beltran, P. J., Cohen, P., Barzilai, N., & Huffman, D. M. (2018). Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nature communications, 9(1), [2394].
12.Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J., Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L. (2018). Senolytics improve physical function and increase lifespan in old age. Nature Medicine, 24(8), 1246-1256.
13.Cunningham, G. M., Flores, L. C., Roman, M. G., Cheng, C., Dube, S., Allen, C., Valentine, J. M., Hubbard, G. B., Bai, Y., Saunders, T. L., & Ikeno, Y. (2018). Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice. GeroScience, 40(5-6), 453-468.
14.Zhang, Y., Unnikrishnan, A., Deepa, S. S., Liu, Y., Li, Y., Ikeno, Y., Sosnowska, D., Van Remmen, H., & Richardson, A. (2017). A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence. Redox Biology, 11, 30-37.
15.Ashpole, N. M., Logan, S., Yabluchanskiy, A., Mitschelen, M. C., Yan, H., Farley, J. A., Hodges, E. L., Ungvari, Z., Csiszar, A., Chen, S., Georgescu, C., Hubbard, G. B., Ikeno, Y., & Sonntag, W. E. (2017). IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. GeroScience, 39(2), 129-145.
16.Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Burón, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C., Broeskamp, F., Habering, L., Dawson, J., Beasley, T. M., Wan, J., Ikeno, Y., Hubbard, G., Becker, K. G., Zhang, Y., Bohr, V. A., Longo, D. L., Navas, P., Ferrucci, L., Sinclair, D. A., Cohen, P., Egan, J. M., Mitchell, J. R., Baur, J. A., Allison, D. B., Anson, R. M., Villalba, J. M., Madeo, F., Cuervo, A. M., Pearson, K. J., Ingram, D. K., Bernier, M. & De Cabo, R. (2016). Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metabolism, 23(6), 1093-1112.
17.Ashpole, N. M., Herron, J. C., Mitschelen, M. C., Farley, J. A., Logan, S., Yan, H., Ungvari, Z., Hodges, E. L., Csiszar, A., Ikeno, Y., Humphrey, M. B., & Sonntag, W. E. (2016). IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. Journal of Bone and Mineral Research, 31(2), 443-454.
18.Zhang, Y., Liu, Y., Walsh, M., Bokov, A., Ikeno, Y., Jang, Y. C., Perez, V. I., Van Remmen, H., & Richardson, A. (2016). Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice. Mechanisms of Ageing and Development, 154, 1-8.
19.Sataranatarajan, K., Ikeno, Y., Bokov, A., Feliers, D., Yalamanchili, H., Lee, H. J., Mariappan, M. M., Tabatabai-Mir, H., Diaz, V., Prasad, S., Javors, M. A., Choudhury, G. G., Hubbard, G. B., Barnes, J. L., Richardson, A., & Kasinath, B. S. (2016). Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 71(7), 850-857.
20.Richardson, A., Austad, S. N., Ikeno, Y., Unnikrishnan, A., & Mccarter, R. J. (2016). Significant life extension by ten percent dietary restriction. Annals of the New York Academy of Sciences, 1363(1), 11-17.
21.Treuting, P. M., Snyder, J. M., Ikeno, Y., Schofield, P. N., Ward, J. M., & Sundberg, J. P. (2016). The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents. Veterinary pathology, 53(2), 244-249.
22.Salmon, A. B., Lerner, C., Ikeno, Y., Perrine, S. M. M., McCarter, R., & Sell, C. (2015). Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I. American Journal of Physiology - Endocrinology and Metabolism, 308(7), E545-E553.
23.Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., Di Biase, S., Mirzaei, H., Mirisola, M. G., Childress, P., Ji, L., Groshen, S., Penna, F., Odetti, P., Perin, L., Conti, P. S., Ikeno, Y., Kennedy, B. K., Cohen, P., Morgan, T. E., Dorff, T. B. & Longo, V. D. (2015). A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism, 22(1), 86-99.
24.Laberge, R. M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., Limbad, C., Demaria, M., Li, P., Hubbard, G. B., Ikeno, Y., Javors, M., Desprez, P. Y., Benz, C. C., Kapahi, P., ... Campisi, J. (2015). MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nature Cell Biology, 17(8), 1049-1061.
25.Ikeno, Y. (2015). New insights and current concepts of the oxidative stress theory of aging. Archives of Biochemistry and Biophysics, 576, 1. [6956].
26.Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., Li, X., Serre, T., Qi, W., Van Remmen, H., Miller, R. A., Bath, K. G., De Cabo, R., Xu, H., Neretti, N., & Sedivy, J. M. (2015). Reduced expression of MYC increases longevity and enhances healthspan. Cell, 160(3), 477-488.
27.List, E. O., Berryman, D. E., Ikeno, Y., Hubbard, G. B., Funk, K., Comisford, R., Young, J. A., Stout, M. B., Tchkonia, T., Masternak, M. M., Bartke, A., Kirkland, J. L., Miller, R. A., & Kopchick, J. J. (2015). Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/-mice. Aging, 7(7), 500-512.
28.Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O’hara, S. P., Larusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., Lebrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., ... Kirkland, J. L. (2015). The achilles’ heel of senescent cells: From transcriptome to senolytic drugs. Aging cell, 14(4), 644-658.