Contact
- (210) 562-6137
Faculty Profile - ikeno@uthscsa.edu
Department
PathologyYuji Ikeno, MD, PhD
Professor
Personal Statement:
Over the past 31 years, I have been directly responsible for the pathological analyses of all animals studied in multiple Program Projects and the San Antonio Nathan Shock Aging Center. In addition to pathological analyses of aging animals, I also have multiple research projects that seek the underlying mechanisms of aging. The primary goal of my research is to test whether changes in oxidative stress and redox status in the cell attenuate aging and age-related pathology, e.g., cancer, obesity, and type-2 diabetes, using unique animal models with altered levels of various antioxidant enzymes, e.g., thioredoxin transgenic/knockout mice, Cu/ZnSOD transgenic rats.
Education
| Year | Degree | Discipline | Institution |
| 1987 | MD | Medicine | Nagasaki University School of Medicine Nagasaki , Japan |
| 1993 | PhD | Medicine/Pathology | Nagasaki University School of Medicine Nagasaki , Japan |
Publications
| 1. | Tandukar, G., Flores, L.C., Allen, C., Bai, Y., and Ikeno, Y. Technical development of Senescence-Associated β-Galactosidase staining in frozen kidney tissue of Sprague Dawley rat. Aging Pathobiol. Ther. 6: 117-124. DOI: 10.31491/APT.2024.09.150. 2024. |
| 2. | Wang, B., Wang, L., Gasek, N.S., Kuo, C.-L., Nie, J., Kim, T., Yan, P., Torrance, B.L., Zhou, Y., Flores, L.C., Allen, C., Andrade, A.M., Guo, C., Cohn, R.L., Jellison, E.R., Kuchel, G.A., Li, S., Pirtskhalava, T., Tchkonia, T., Haynes, L., Kirkland, J.L., Ikeno, Y., and Xu, M. Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function. Cell Metabolism. 36: 1795-1805. DOI:10.1016/j.cmet.2024.07006. 2024. |
| 3. | Clark A, Villarreal MR, Rivas P, Huang S-B, Jayamohan S, Hussain SS, Ybarra M, Osmulski P, Gaczynska ME, Yang X, Exhilan CXP, Natarajan M, Pierce BL, Lai Z, Wang L-J, Michalek JE, Higginson DS, Ikeno Y, Chen Y, Ghosh R, and Kumar AP. Targeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in prostate cancer. Cancer Lett. 2024: 597: 217063. doi: 10.1016/j.canlet.2024.217063. |
| 4. | Wen Y, Zhang X, Cacciani N, Hedstrom Y, Ikeno Y, Bergquist J, and Larsson L. Proteomics panel of BAL fluid associated with the ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2024; 71(1): 12-15. doi: 10.1165/rcmb.2023-0431LE. PMID: 38949323. |
| 5. | Ikeno Y. Ethylnitrosourea-induced gliomas: a song in the attic? Aging Pathobiol Ther. 2023;5(2):48-51. Epub 20230628. doi: 10.31491/apt.2023.06.111. PubMed PMID: 38487310; PMCID: PMC10939132. |
| 6. | Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. J Clin Invest. 2023;133(8). Epub 20230417. doi: 10.1172/jci162519. PubMed PMID: 36809340; PMCID: PMC10104901. |
| 7. | Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nature Communications. 2022;13(1):4827. doi: 10.1038/s41467-022-32552-1. |
| 8. | Liang T, Dunn J, Zou X, Nayak B, Ikeno Y, Fan L, Bai Y. Characterizing the Electron Transport Chain: Functional Approach Using Extracellular Flux Analyzer on Mouse Tissue Samples. Methods Mol Biol. 2022;2497:117-28. doi: 10.1007/978-1-0716-2309-1_8. PubMed PMID: 35771439. |
| 9. | Liang T, Deng J, Nayak B, Zou X, Ikeno Y, Bai Y. Characterizing the Electron Transport Chain: Structural Approach. Methods Mol Biol. 2022;2497:107-15. doi: 10.1007/978-1-0716-2309-1_7. PubMed PMID: 35771438. |
| 10. | Chandra A, Lagnado AB, Farr JN, Doolittle M, Tchkonia T, Kirkland JL, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Ikeno Y, Passos JF, Monroe DG, Pignolo RJ, Khosla S. Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity. Aging Cell. 2022;21(5):e13602. Epub 20220401. doi: 10.1111/acel.13602. PubMed PMID: 35363946; PMCID: PMC9124310. |
| 11. | Ikeno Y. Thioredoxin - a magic bullet or a double-edged sword for mammalian aging? Aging Pathobiol Ther. 2021;3(2):17-9. Epub 20210629. doi: 10.31491/apt.2021.06.056. PubMed PMID: 35368730; PMCID: PMC8974492. |
| 12. | Lee, H. J., Donati, A., Feliers, D., Sun, Y., Ding, Y., Madesh, M., Salmon, A. B., Ikeno, Y., Ross, C., O'Connor, C. L., Ju, W., Bitzer, M., Chen, Y., Choudhury, G. G., Singh, B. B., Sharma, K., & Kasinath, B. S. (2021). Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury. Aging cell, 20(7), [e13407]. https://doi.org/10.1111/acel.13407 |
| 13. | Duran-Ortiz, S., List, E. O., Ikeno, Y., Young, J., Basu, R., Bell, S., McHugh, T., Funk, K., Mathes, S., Qian, Y., Kulkarni, P., Yakar, S., Berryman, D. E., & Kopchick, J. J. (2021). Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan. Aging cell, 20(12), [e13506]. https://doi.org/10.1111/acel.13506 |
| 14. | Cantwell, A. M., Singh, H., Platt, M., Yu, Y., Lin, Y. H., Ikeno, Y., Hubbard, G., Xiang, Y., Gonzalez-Juarbe, N., & Dube, P. H. (2021). Kinetic multi-omic analysis of responses to SARS-CoV-2 infection in a model of severe COVID-19. Journal of virology, 95(20), [e01010-21]. https://doi.org/10.1128/JVI.01010-21 |
| 15. | Salmon, A. B., Nelson, J. F., Gelfond, J. A. L., Javors, M., Ginsburg, B., Lopez-Cruzan, M., Galvan, V., Fernandez, E., Musi, N., Ikeno, Y., Hubbard, G., Lechleiter, J., Hornsby, P. J., & Strong, R. (2021). San Antonio Nathan Shock Center: your one-stop shop for aging research. GeroScience, 43(5), 2105-2118. https://doi.org/10.1007/s11357-021-00417-y |
| 16. | Poudel, S. B., Dixit, M., Yildirim, G., Cordoba-Chacon, J., Gahete, M. D., Yuji, I., Kirsch, T., Kineman, R. D., & Yakar, S. (2021). Sexual dimorphic impact of adult-onset somatopause on life span and age-induced osteoarthritis. Aging cell, 20(8), [e13427]. https://doi.org/10.1111/acel.13427 |
| 17. | Jiang, Z., Bahr, T., Zhou, C., Jin, T., Chen, H., Song, S., Ikeno, Y., Tian, H., & Bai, Y. (2020). Diagnostic value of circulating cell-free mtDNA in patients with suspected thyroid cancer: ND4/ND1 ratio as a new potential plasma marker. Mitochondrion, 55, 145-153. https://doi.org/10.1016/j.mito.2020.09.007 |
| 18. | Souza LdCM, Chen M, Ikeno Y, Salvadori DMF, Bai Y. The implications of mitochondria in doxorubicin treatment of cancer in the context of traditional and modern medicine. Traditional Medicine and Modern Medicine. 2020;03(04):239-54. doi: 10.1142/s2575900020300076. |
| 19. | Roman MG, Flores LC, Cunningham GM, Cheng C, Dube S, Allen C, Van Remmen H, Bai Y, Hubbard GB, Saunders TL, Ikeno Y. Thioredoxin overexpression in mitochondria showed minimum effects on aging and age-related diseases in male C57BL/6 mice. Aging Pathobiol Ther. 2020;2(1):20-31. Epub 20200327. doi: 10.31491/apt.2020.03.009. PubMed PMID: 35356005; PMCID: PMC8963792. |
| 20. | Roman MG, Flores LC, Cunningham GM, Cheng C, Allen C, Hubbard GB, Bai Y, Saunders TL, Ikeno Y. Thioredoxin and aging: What have we learned from the survival studies? Aging Pathobiol Ther. 2020;2(3):126-33. doi: 10.31491/apt.2020.09.028. PubMed PMID: 35493763; PMCID: PMC9049237. |
| 21. | Olstad KJ, Imai DM, Keesler RI, Reader R, Morrison JH, Roberts JA, Capitanio JP, Didier ES, Kuroda MJ, Simmons H, Salimi S, Mattison JA, Ikeno Y, Ladiges W. Development of a Geropathology Grading Platform for nonhuman primates. Aging Pathobiol Ther. 2020;2(1):16-9. doi: 10.31491/apt.2020.03.008. PubMed PMID: 33283205; PMCID: PMC7717498. |
| 22. | Ikeno Y, Flores LC. Oxidative stress and aging; stayin' alive? Aging Pathobiol Ther. 2020;2:20-31. doi: DOI: 10.31491/APT.2020.06.015. |
| 23. | Colon G, Saccon T, Schneider A, Cavalcante MB, Huffman DM, Berryman D, List E, Ikeno Y, Musi N, Bartke A, Kopchick J, Kirkland JL, Tchkonia T, Masternak MM. The enigmatic role of growth hormone in age-related diseases, cognition, and longevity. Geroscience. 2019;41(6):759-74. Epub 20190904. doi: 10.1007/s11357-019-00096-w. PubMed PMID: 31485887; PMCID: PMC6925094. |
| 24. | Camell, C. D., Günther, P., Lee, A., Goldberg, E. L., Spadaro, O., Youm, Y. H., Bartke, A., Hubbard, G. B., Ikeno, Y., Ruddle, N. H., Schultze, J., & Dixit, V. D. (2019). Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metabolism, 30(6), 1024-1039.e6. https://doi.org/10.1016/j.cmet.2019.10.006 |
| 25. | Mitchell, S. J., Bernier, M., Mattison, J. A., Aon, M. A., Kaiser, T. A., Anson, R. M., Ikeno, Y., Anderson, R. M., Ingram, D. K., & de Cabo, R. (2019). Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories. Cell Metabolism, 29(1), 221-228.e3. https://doi.org/10.1016/j.cmet.2018.08.011 |
| 26. | Habermehl, T. L., Parkinson, K. C., Hubbard, G. B., Ikeno, Y., Engelmeyer, J. I., Schumacher, B., & Mason, J. B. (2019). Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice. GeroScience, 41(1), 25-38. https://doi.org/10.1007/s11357-018-0049-4 |
| 27. | Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., ... Jurk, D. (2019). Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metabolism, 29(5), 1061-1077.e8. https://doi.org/10.1016/j.cmet.2018.12.008 |
| 28. | Mao, K., Quipildor, G. F., Tabrizian, T., Novaj, A., Guan, F., Walters, R. O., Delahaye, F., Hubbard, G. B., Ikeno, Y., Ejima, K., Li, P., Allison, D. B., Salimi-Moosavi, H., Beltran, P. J., Cohen, P., Barzilai, N., & Huffman, D. M. (2018). Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nature communications, 9(1), [2394]. https://doi.org/10.1038/s41467-018-04805-5 |
| 29. | Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J., Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L. (2018). Senolytics improve physical function and increase lifespan in old age. Nature Medicine, 24(8), 1246-1256. https://doi.org/10.1038/s41591-018-0092-9 |
| 30. | Cunningham, G. M., Flores, L. C., Roman, M. G., Cheng, C., Dube, S., Allen, C., Valentine, J. M., Hubbard, G. B., Bai, Y., Saunders, T. L., & Ikeno, Y. (2018). Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice. GeroScience, 40(5-6), 453-468. https://doi.org/10.1007/s11357-018-0039-6 |
| 31. | Zhang, Y., Unnikrishnan, A., Deepa, S. S., Liu, Y., Li, Y., Ikeno, Y., Sosnowska, D., Van Remmen, H., & Richardson, A. (2017). A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence. Redox Biology, 11, 30-37. https://doi.org/10.1016/j.redox.2016.10.014 |
| 32. | Ashpole, N. M., Logan, S., Yabluchanskiy, A., Mitschelen, M. C., Yan, H., Farley, J. A., Hodges, E. L., Ungvari, Z., Csiszar, A., Chen, S., Georgescu, C., Hubbard, G. B., Ikeno, Y., & Sonntag, W. E. (2017). IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. GeroScience, 39(2), 129-145. https://doi.org/10.1007/s11357-017-9971-0 |
| 33. | Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Burón, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C., Broeskamp, F., Habering, L., Dawson, J., Beasley, T. M., Wan, J., Ikeno, Y., Hubbard, G., Becker, K. G., Zhang, Y., Bohr, V. A., Longo, D. L., Navas, P., Ferrucci, L., Sinclair, D. A., Cohen, P., Egan, J. M., Mitchell, J. R., Baur, J. A., Allison, D. B., Anson, R. M., Villalba, J. M., Madeo, F., Cuervo, A. M., Pearson, K. J., Ingram, D. K., Bernier, M. & De Cabo, R. (2016). Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metabolism, 23(6), 1093-1112. https://doi.org/10.1016/j.cmet.2016.05.027 |
| 34. | Ashpole, N. M., Herron, J. C., Mitschelen, M. C., Farley, J. A., Logan, S., Yan, H., Ungvari, Z., Hodges, E. L., Csiszar, A., Ikeno, Y., Humphrey, M. B., & Sonntag, W. E. (2016). IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. Journal of Bone and Mineral Research, 31(2), 443-454. https://doi.org/10.1002/jbmr.2689 |
| 35. | Zhang, Y., Liu, Y., Walsh, M., Bokov, A., Ikeno, Y., Jang, Y. C., Perez, V. I., Van Remmen, H., & Richardson, A. (2016). Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice. Mechanisms of Ageing and Development, 154, 1-8. https://doi.org/10.1016/j.mad.2016.01.005 |
| 36. | Sataranatarajan, K., Ikeno, Y., Bokov, A., Feliers, D., Yalamanchili, H., Lee, H. J., Mariappan, M. M., Tabatabai-Mir, H., Diaz, V., Prasad, S., Javors, M. A., Choudhury, G. G., Hubbard, G. B., Barnes, J. L., Richardson, A., & Kasinath, B. S. (2016). Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 71(7), 850-857. https://doi.org/10.1093/gerona/glv170 |
| 37. | Richardson, A., Austad, S. N., Ikeno, Y., Unnikrishnan, A., & Mccarter, R. J. (2016). Significant life extension by ten percent dietary restriction. Annals of the New York Academy of Sciences, 1363(1), 11-17. https://doi.org/10.1111/nyas.12982 |
| 38. | Treuting, P. M., Snyder, J. M., Ikeno, Y., Schofield, P. N., Ward, J. M., & Sundberg, J. P. (2016). The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents. Veterinary pathology, 53(2), 244-249. https://doi.org/10.1177/0300985815620629 |
| 39. | Salmon, A. B., Lerner, C., Ikeno, Y., Perrine, S. M. M., McCarter, R., & Sell, C. (2015). Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I. American Journal of Physiology - Endocrinology and Metabolism, 308(7), E545-E553. https://doi.org/10.1152/ajpendo.00558.2014 |
| 40. | Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., Di Biase, S., Mirzaei, H., Mirisola, M. G., Childress, P., Ji, L., Groshen, S., Penna, F., Odetti, P., Perin, L., Conti, P. S., Ikeno, Y., Kennedy, B. K., Cohen, P., Morgan, T. E., Dorff, T. B. & Longo, V. D. (2015). A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism, 22(1), 86-99. https://doi.org/10.1016/j.cmet.2015.05.012 |
| 41. | Laberge, R. M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., Limbad, C., Demaria, M., Li, P., Hubbard, G. B., Ikeno, Y., Javors, M., Desprez, P. Y., Benz, C. C., Kapahi, P., ... Campisi, J. (2015). MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nature Cell Biology, 17(8), 1049-1061. https://doi.org/10.1038/ncb3195 |
| 42. | Ikeno, Y. (2015). New insights and current concepts of the oxidative stress theory of aging. Archives of Biochemistry and Biophysics, 576, 1. [6956]. https://doi.org/10.1016/j.abb.2015.03.019 |
| 43. | Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., Li, X., Serre, T., Qi, W., Van Remmen, H., Miller, R. A., Bath, K. G., De Cabo, R., Xu, H., Neretti, N., & Sedivy, J. M. (2015). Reduced expression of MYC increases longevity and enhances healthspan. Cell, 160(3), 477-488. https://doi.org/10.1016/j.cell.2014.12.016 |
| 44. | List, E. O., Berryman, D. E., Ikeno, Y., Hubbard, G. B., Funk, K., Comisford, R., Young, J. A., Stout, M. B., Tchkonia, T., Masternak, M. M., Bartke, A., Kirkland, J. L., Miller, R. A., & Kopchick, J. J. (2015). Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/-mice. Aging, 7(7), 500-512. https://doi.org/10.18632/aging.100766 |
| 45. | Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O’hara, S. P., Larusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., Lebrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., ... Kirkland, J. L. (2015). The achilles’ heel of senescent cells: From transcriptome to senolytic drugs. Aging cell, 14(4), 644-658. https://doi.org/10.1111/acel.12344 |