Kevin Koronowski, PhD

Research

Circadian Rhythms; Circadian Clock, Metabolism and Metabolic Disease, Molecular Biology, Genetic Mouse Models

Laboratory projects aim to better our understanding of how metabolism is regulated across time (over the course of a day) and space (between cells and organs of the body). Acquiring this knowledge will help identify root causes of, and potential therapies for, metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and cancer. We model metabolic health and disease in cultured cells and mice using environmental, dietary and genetic tools that disrupt the circadian clock, a biological system tied to metabolic health. We employ cutting-edge techniques in metabolomics, molecular biology and in vivo metabolism.

Related Diseases: Circadian Rhythm Disruption, Obesity, Type 2 diabetes, Metabolic syndrome

Techniques: Light- and food-based circadian entrainment, clock knockout and reconstitution mouse models, behavioral assays, cellular bioenergetics, live cell imaging and luciferase reporters, cell conditioned media and co-cultures, RNA sequencing and real-time quantitative PCR, chromatin-immunoprecipitation, LC-MS metabolomics, substrate tolerance tests, others

Publications

https://scholars.uthscsa.edu/en/persons/kevin-koronowski