Safety and efficacy of dietary supplement including ursolic acid
Purpose of this Study
In this study, we are trying to understand whether a certain dietary supplement can help muscle health in humans. The dietary supplement contains an extract from rosemary, an herb and natural food that contains a compound called ursolic acid. Ursolic acid also comes from apples and many other natural foods (fruits and herbs). Previous studies have shown that ursolic acid may help muscle health in mice, rats, dogs, and humans. Through studies like this one, our long-term goal is to try and develop a dietary supplement that can be made available to many people to help their muscles.
Objectives:
- To determine if the dietary supplement with ursolic acid results in beneficial changes in muscle
- To evaluate if this dose of dietary supplement with ursolic results in changes in ursolic acid in the blood
- To monitor for safety of dietary supplement with ursolic acid taken once a day for 12 weeks
You may be able to join the study if:
- Male or female
- Age 50-65
- Overall healthy
- Body mass index between 22.0-34.9 kg/m2
You may NOT qualify if:
- Heart Disease
- Diabetes
- Systemic autoimmune or inflammatory conditions like Lupus or Rheumatoid Arthritis
- Moderate or high intensity exercise more than twice a week in the past 6 months
Duration of the Study:
12 weeks
Study Procedures:
- Medical History
- Physical examination/assessment
- Blood tests
- Strength testing of hands and legs
- Determining maximum effort on a stationary bike
- Muscle tissue biopsy
Study Locations:
UT Health San Antonio
Sam and Ann Barshop Institute for Longevity and Aging Studies
4939 Charles Katz Dr.
San Antonio, TX 78229
Compensation:
You may earn up to $1,000 for completing all study-related visits.
Principal Investigator:
Tiffany Cortes, MD
Contact Us
For more information or to volunteer in a study:
- Call (210) 450-3333
- If you prefer that we contact you, please fill out the form below.
