Barshop Institute
March 23, 2021
The paper has been accepted for publication in the Journal of Neuroscience. The paper has also been selected as “noteworthy” and will be featured as highlighted research in the journal’s webpage and in all their social media streams and digital communications.
January 5, 2021
The paper is titled “Proximal tubular epithelial insulin receptor mediates high fat diet-induced kidney injury” by Hak Joo Lee, Meenalakshmi M. Mariappan, Luke Norton, Terry Bakewell, Denis Feliers, Sae Byeol Oh, Andrew Donati, Cherubina S. Rubannelsonkumar, Manjeri A. Venkatachalam, Stephen E. Harris, Isabelle Rubera, Michel Tauc, Goutam Ghosh Choudhury, C. Ronald Kahn, Kumar Sharma, Ralph […]
December 23, 2020
TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A Jun Ho Ko, Mi Young Son, Qing Zhou, Lucia Molnarova, Lambert Song, Jarmila Mlcouskova, Atis Jekabsons, Cristina Montagna, Lumir Krejci, Paul Hasty Cell Reports. Volume 33, Issue 12, 22 December 2020, 108543. doi: 10.1016/j.celrep.2020.108543. Summary: DNA damage tolerance (DDT) and homologous […]
November 24, 2020
The paper is titled “Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes” by Juan P. Palavicini, Juan Chen, Chunyan Wang, Jianing Wang, Chao Qin, Eric Baeuerle, Xinming Wang, Jung A. Woo, David E. Kang, Nicolas Musi, Jeffrey L. Dupree, and Xianlin Han. Dr. Palavicini is an Assistant Professor/Research with the Sam […]
July 24, 2020
The paper is titled “Aster-B Coordinates with Arf1 to Regulate Mitochondrial Cholesterol Transport” by John-Paul Andersen, Jun Zhang, Haoran Sun, Xuyun Liu, Jiankang Liu, Jia Nie, and Yuguang Shi and will be published in an upcoming issue of Molecular Metabolism. John-Paul Andersen is a graduate student in the laboratory of Roger Shi, PhD. ABSTRACT: Objective: […]
July 20, 2020
Dr. Frost and her lab have a new paper published in Cell Reports. Highlights •TauR406W induces nuclear CREB depletion in neurons of the adult Drosophila brain •Nuclear Ca2+ decreases with aging and tauopathy in the adult Drosophila brain •Nuclear Ca2+ is depleted in iPSC-derived neurons from sporadic Alzheimer’s disease •Pharmacologic/genetic manipulation of BK channels modify […]
June 12, 2020
The paper is titled “Aster-C Coordinates with COP I Vesicles to Regulate Lysosomal Trafficking and Activation of mTORC1” by Jun Zhang, John-Paul Andersen, Haoran Sun, Nahum Sonenberg, Jia Nie, and Yuguang Shi and will be published in an upcoming issue of EMBO Reports. John-Paul Andersen is a graduate student in the laboratory of Roger Shi, […]
May 21, 2020
Dr. Chen, an assistant professor at the Sam and Ann Barshop Institute for Longevity and Aging Studies, collaborated with biologists at the Mays Cancer Center and researchers in Paris, France, and Shanghai, China, to identify important drivers of tumor resistance. https://www.sciencedaily.com/releases/2020/05/200518144906.htm
April 30, 2020
The paper, titled “mTOR drives cerebrovascular, synaptic and cognitive dysfunction in normative aging” was among the 10% most downloaded papers in the journal Aging Cell (between Jan 2018 and Dec 2019). mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging. Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier […]
February 21, 2020
Awakening the dark side: retrotransposon activation in neurodegenerative disorders. Elizabeth Ochoa Thomas, Gabbe Zuniga, Wenyan Sun, Bess Frost. Current Opinion in Neurobiology. 2020 Apr;61:65-72. doi: 10.1016/j.conb.2020.01.012. Epub 2020 Feb 21. Abstract: Nearly half (45%) of the human genome is composed of transposable elements, or ‘jumping genes’. Since Barbara McClintock’s original discovery of transposable elements in […]