Barshop Institute
February 19, 2025
Congratulations to the lab of Dr. Ann Griffith. Their work demonstrates how the thymus is protected during aging by FGF21, providing potential targets for immune aging. Dr. Griffith is an Assistant Professor in the Department of Microbiology, Immunology & Molecular Genetics. Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan Sarah […]
February 14, 2025
The manuscript, “A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice,” was published in Nature Aging. In the paper, they reported the discovery of the first liver tropic senolytic BCL-xL and BCL-2 PROTAC 753b, which can selectively reduce senescent cells in the liver in aged mice and […]
February 5, 2025
The outcomes of this study suggest that targeting the cGAS-STING signaling pathway is a potential therapeutic strategy for Alzheimer’s disease. Dr. Xianlin Han is a professor in the Department of Medicine, Division of Diabetes and an investigator with the Sam and Ann Barshop Institute for Longevity and Aging Studies. Dr. Sijia He is an Assistant […]
January 28, 2025
Their study characterizes the role of adiponectin in the development of age-related liver fibrosis. Dr. Zhao is an assistant professor in the Department of Medicine, Division of Endocrinology and an investigator with the Sam and Ann Barshop Institute for Longevity and Aging Studies. The adiponectin-PPARγ axis in hepatic stellate cells regulates liver fibrosis Shangang Zhao, […]
January 27, 2025
Their study identifies the process of ferroptosis as a potential target to preserve neuronal function and innervation with aging. Dr. Chen is the holder of the Bartell Zachry Memorial Distinguished Professorship for Research in Neurodegenerative Diseases, an Associate Professor with the Department of Cell Systems and Anatomy, and an investigator with the Sam and Ann […]
May 19, 2024
Dr. Gius is a Professor of Radiation Oncology, the Assistant Dean for Research with the Joe R. & Teresa Lozano Long School of Medicine, and the Associate Cancer Center Director with the Mays Cancer Center at UT Health San Antonio MD Anderson. Ketogenic diet induces p53-dependent cellular senescence in multiple organs Sung-Jen Wei, Joseph R Schell, E Sandra Chocron, Mahboubeh […]
May 18, 2024
Dr. Gius is a Professor of Radiation Oncology, the Assistant Dean for Research with the Joe R. & Teresa Lozano Long School of Medicine, and the Associate Cancer Center Director with the Mays Cancer Center at UT Health San Antonio MD Anderson. Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease Guogang Xu, Songhua […]
May 15, 2024
Original story: UT Health San Antonio Newsroom MoTrPAC releases seven publications this month We all know that exercise is good for us, but figuring out the “why” and “how” of physical exercise’s effect on the body is the goal of a 10-year, multi-million dollar project through the National Institutes of Health called the Molecular Transducers […]
May 3, 2024
Dr. Koronowski is an Assistant Professor with the Sam and Ann Barshop Institute for Longevity and Aging Studies and the Department of Biochemistry and Structural Biology. Brain-muscle communication prevents muscle aging by maintaining daily physiology Arun Kumar, Mireia Vaca-Dempere, Thomas Mortimer, Oleg Deryagin, Jacob G Smith, Paul Petrus, Kevin B Koronowski, Carolina M Greco, Jessica […]
May 2, 2024
Nisi Jiang is a PhD student in the Biology of Aging discipline under the mentorship of Dr. James Nelson. The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride Nisi Jiang, Jonathan Gelfond, Qianqian Liu, Randy […]
