Barshop Institute
August 19, 2025
A new study from post-doctoral fellow Kevin Thyne, PhD, shows that methionine restriction, a dietary intervention known to extend lifespan, has different effects on mitochondria and signaling mechanisms that dependent on which tissues are tested, and which sex of mice are tested. Dr. Thyne is a postdoctoral fellow in the lab of Adam Salmon, PhD, […]
August 15, 2025
Highlights: This review explores ferroptosis, an iron-dependent, non-apoptotic form of programmed cell death, as a promising strategy for eliminating senescent cells, which accumulate with age and contribute to tissue dysfunction and age-related diseases such as fibrosis, atherosclerosis, osteoarthritis, and neurodegeneration. The molecular mechanisms of ferroptosis, including iron overload, lipid peroxidation, and oxidative damage, can be […]
August 14, 2025
Study Highlights Skeletal Muscle Changes During Disuse and Rehabilitation A recent study from the lab of Blake Rasmussen, PhD, and published in Physiological Reports examined how short-term skeletal muscle disuse and subsequent rehabilitation affect muscle function and gene expression in healthy middle-aged adults. Participants underwent seven days of unilateral lower-limb suspension followed by a two-week […]
July 29, 2025
Original story: UT Health San Antonio Newsroom Contact: Claire Kowalick, kowalick@uthscsa.edu SAN ANTONIO (July 28, 2025) — Study finds rapamycin shows greatest longevity effect in 20-year NIH Interventions Testing Program The first comprehensive review of two decades of research from the National Institute on Aging’s Interventions Testing Program highlights 13 interventions that show promise in preclinical […]
May 30, 2025
A review from Biology of Aging PhD student Christopher Litwin addresses the role of the liver in regulating circadian rhythm and metabolism. Christopher is a PhD student in the lab of Kevin Koronowski, PhD. Dr. Koronowski is an Assistant Professor with the Department of Biochemistry and Structural Biology and a Principal Investigator with the Sam […]
May 29, 2025
A new study from Barshop Investigators Ellen Kraig, PhD, and Dean Kellogg, Jr, MD, PhD, examines targeting the biology of aging with rapamycin to treat Alzheimer’s disease in a pilot clinical trial. Dr. Kraig is a Professor in the Department of Cell Systems and Anatomy. Dr. Kellogg is a Professor in the Department of Medicine, […]
May 14, 2025
Erik Marchant, a third year PhD student, has published his first paper from his dissertation. Erik used low-frequency ultrasound in old mice with insulin resistance and diabetes and discovered many interesting transcriptomic changes in skeletal muscle that reduce inflammation and alter immune cell function. Erik is a PhD student in the lab of Blake Rasmussen, […]
May 5, 2025
Sean Kilroe, PhD, has published his first paper as a postdoctoral fellow in the lab of Blake Rasmussen, PhD. Dr. Kilroe used a multi-omics approach to outline which metabolic pathways are impacted in human skeletal muscle in response to physical inactivity. Dr. Rasmussen is Professor and Chair of the Department of Cellular & Integrative Physiology, […]
April 19, 2025
Original story: UT Health San Antonio Newsroom Discovery of chemical endocytosis could redefine precision medicine Contact: Claire Kowalick, kowalick@uthscsa.edu SAN ANTONIO (April 18, 2025) — A team of scientists, notably Zhengyu Wang, PhD, assistant professor in the department of pharmacology and the Barshop Institute, led by Hong-yu Li, PhD, professor of medicinal chemistry and chemical […]
April 15, 2025
Anya Kalenta, a final year PhD student, has published her first first-author publication. In this study, they investigated how an acute bout of treadmill running alters the skeletal muscle metabolome and lipidome in mice with hyperactive mTORC1 signaling. Anya is a PhD student in the lab of Blake Rasmussen, PhD at the Sam and Ann […]
