Congratulations to Dr. Veronica Galvan for her publication in Science Translational Medicine

February 4, 2019

Rapamycin and Alzheimer’s disease: Time for a clinical trial? Kaeberlein M, Galvan V Sci Transl Med. 2019 Jan 23;11(476). pii: eaar4289. doi: 10.1126/scitranslmed.aar4289. Abstract: The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer’s disease. Despite its compelling preclinical record, no clinical trials have […]

Congratulations to Dr. Lizhen Chen for her publication in Aging Cell

February 4, 2019

Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF‐16 in C. elegans. Aiping Xu, Zhao Zhang, Su‐Hyuk Ko, Alfred L. Fisher, Zhijie Liu, Lizhen Chen Aging Cell. 14 January 2019. doi: 10.1111/acel.12884. [Epub ahead of print]. Abstract: Microtubule (MT) regulation is involved in both neuronal function and the maintenance […]

Congratulations to Dr. Adam Salmon for his publication in the American Journal of Primatology

December 19, 2018

Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB American Journal of Primatology. 2018 Oct 12:e22927. doi: 10.1002/ajp.22927. [Epub ahead of print]. Abstract: Interventions to extend lifespan and improve health with increasing age would have significant impact […]

Congratulations to Dr. Masahiro Morita for his publication in Cell Metabolism

December 18, 2018

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, […]

Congratulations to Dr. Nicolas Musi for his publication in PLOS ONE

December 14, 2018

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp. Blanco CL, Gastaldelli A, Anzueto DG, Winter LA, Seidner SR, McCurnin DC, Liang H, Javors MA, DeFronzo RA, Musi N PLoS one. 2018 Dec 12;13(12):e0208757. doi: 10.1371/journal.pone.0208757. eCollection 2018. Abstract: Premature baboons exhibit peripheral insulin resistance and impaired […]

Congratulations to Dr. Nicolas Musi for his publication in The Journals of Gerontology

December 14, 2018

NFκB Regulates Muscle Development and Mitochondrial Function. Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N J Gerontol A Biol Sci Med Sci. 2018 Nov 13. doi: 10.1093/gerona/gly262. [Epub ahead of print] Abstract: NFκB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated […]

Congratulations to Dr. Bess Frost for her publication in Aging Cell

November 12, 2018

Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila Cornelison GL, Levy SA, Jenson T, Frost B Aging Cell. 2018 Nov 9:e12847. doi: 10.1111/acel.12847. [Epub ahead of print] Abstract: The nucleus is a spherical dual-membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and […]

Congratulations to Dr. Balakuntalam Kasinath for his publication in The Journals of Gerontology

October 26, 2018

Marmoset as a model to study kidney changes associated with aging. Lee HJ, Gonzalez O, Dick EJ Jr, Donati A, Feliers D, Goutam Ghosh C, Ross C, Venkatachalam M, Tardif SD, Kasinath BS J Gerontol A Biol Sci Med Sci. 2018 Oct 13. doi: 10.1093/gerona/gly237. [Epub ahead of print] DOI: 10.1093/gerona/gly237 Abstract: We evaluated whether […]

Congratulations to Dr. Balakuntalam Kasinath for his publication in Geroscience

October 26, 2018

Hydrogen sulfide ameliorates aging-associated changes in the kidney. Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG2, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS Geroscience. 2018 Apr;40(2):163-176. doi: 10.1007/s11357-018-0018-y. Epub 2018 May 1. PMCID: PMC5964063 Abstract: Aging is associated with replacement of normal kidney parenchyma by fibrosis. […]

Congratulations to Dr. Mengwei Zang for her publication in Hepatology

August 25, 2018

DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher […]