Publications
Congratulations to Paul Hasty, DVM on his publication in Aging Cell!
January 6, 2020
Acarbose improved survival for Apc+/Min mice Sherry G Dodds, Manish Parihar, Martin Javors, Jia Nie, Nicolas Musi, Zelton Dave Sharp, Paul Hasty Aging Cell. 2020 Feb;19(2):e13088. doi: 10.1111/acel.13088. Epub 2020 Jan 6. Abstract: Acarbose blocks the digestion of complex carbohydrates, and the NIA Intervention Testing Program (ITP) found that it improved survival when fed to […]
Congratulations to Dr. Masahiro Morita for his publication in PNAS.
May 20, 2019
Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N PNAS. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 […]
Congratulations to Dr. James Nelson for his publication in Aging Cell
May 17, 2019
Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice. Allen BD, Liao CY, Shu J, Muglia LJ, Majzoub JA, Diaz V, Nelson JF Aging Cell. 2019 Jun;18(3):e12944. doi: 10.1111/acel.12944. Epub 2019 Apr 1. Abstract: Calorie restriction (CR), which lengthens lifespan in many species, is associated with moderate hyperadrenocorticism and attenuated inflammation. Given the […]
Congratulations to Dr. Veronica Galvan for her publication in Science Translational Medicine
February 4, 2019
Rapamycin and Alzheimer’s disease: Time for a clinical trial? Kaeberlein M, Galvan V Sci Transl Med. 2019 Jan 23;11(476). pii: eaar4289. doi: 10.1126/scitranslmed.aar4289. Abstract: The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer’s disease. Despite its compelling preclinical record, no clinical trials have […]
Congratulations to Dr. Lizhen Chen for her publication in Aging Cell
February 4, 2019
Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF‐16 in C. elegans. Aiping Xu, Zhao Zhang, Su‐Hyuk Ko, Alfred L. Fisher, Zhijie Liu, Lizhen Chen Aging Cell. 14 January 2019. doi: 10.1111/acel.12884. [Epub ahead of print]. Abstract: Microtubule (MT) regulation is involved in both neuronal function and the maintenance […]
Congratulations to Dr. Adam Salmon for his publication in the American Journal of Primatology
December 19, 2018
Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB American Journal of Primatology. 2018 Oct 12:e22927. doi: 10.1002/ajp.22927. [Epub ahead of print]. Abstract: Interventions to extend lifespan and improve health with increasing age would have significant impact […]
Congratulations to Dr. Masahiro Morita for his publication in Cell Metabolism
December 18, 2018
Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, […]
Congratulations to Dr. Nicolas Musi for his publication in PLOS ONE
December 14, 2018
Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp. Blanco CL, Gastaldelli A, Anzueto DG, Winter LA, Seidner SR, McCurnin DC, Liang H, Javors MA, DeFronzo RA, Musi N PLoS one. 2018 Dec 12;13(12):e0208757. doi: 10.1371/journal.pone.0208757. eCollection 2018. Abstract: Premature baboons exhibit peripheral insulin resistance and impaired […]
Congratulations to Dr. Nicolas Musi for his publication in The Journals of Gerontology
December 14, 2018
NFκB Regulates Muscle Development and Mitochondrial Function. Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N J Gerontol A Biol Sci Med Sci. 2018 Nov 13. doi: 10.1093/gerona/gly262. [Epub ahead of print] Abstract: NFκB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated […]
Congratulations to Dr. Bess Frost for her publication in Aging Cell
November 12, 2018
Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila Cornelison GL, Levy SA, Jenson T, Frost B Aging Cell. 2018 Nov 9:e12847. doi: 10.1111/acel.12847. [Epub ahead of print] Abstract: The nucleus is a spherical dual-membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and […]