The paper, titled “Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD mice,” explores how microglia, the brain’s immune cells, regulate lipid metabolism and contribute to Alzheimer’s disease progression. By studying microglial depletion in a mouse model of Alzheimer’s, the research provides new insights into how these cells influence disease mechanisms at the molecular level.
This important discovery advances our understanding of the link between immune function and neurodegeneration, offering potential new directions for Alzheimer’s research and therapeutic development.
Ziying Xu is a Biology of Aging PhD Candidate in the lab of Xianlin Han, PhD. Dr. Han is a Professor with the Department of Medicine, Division of Diabetes and a Principal Investigator with the Sam and Ann Barshop Institute for Longevity and Aging Studies.
Read the full paper in Nature Communications.