Barshop Institute
March 31, 2025
A new publication from Daniel Adekunbi, PhD, shows that aging is associated with a significant decline in mitochondrial bioenergetics in the brain in a non-human primate model of aging. This loss of energetics is associated with a similar decline in walking speed with age, highlighting a potential mechanism for increased frailty and loss of function […]
March 27, 2025
A new study from the lab of Kevin Koronowski, PhD, looks at the effect of chronic jet lag in mice on their behavior and metabolism dysfunction in the liver. This study shows that misalignment of the normal circadian rhythm can have long-term functional consequences that may deteriorate aging health. Dr. Koronowski is an Assistant Professor […]
March 19, 2025
A new paper from the lab of David Gius, MD, PhD, and supported by the Shock Center GeroMetabolism Core, uses a novel mouse model targeting mitochondrial acetylation to identify potential functional mechanisms of ketogenic diets on lipid metabolism. Dr. Gius is a Professor of Radiation Oncology, the Assistant Dean for Research with the Joe R. […]
March 18, 2025
Congratulations to Pepper Center Core Leader Tiffany Cortes, MD, on her new paper outlining the importance of addressing lifestyle-based approaches to preserving bone and muscle with weight loss in older patients and identify best practices for doing so. Dr. Cortes is an Assistant Professor/Clinical in the Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes. […]
March 12, 2025
Support from the San Antonio Nathan Shock Center Animal Core contributed to a recent publication of translation of 17α-estradiol as a gerotherapeutic intervention in non-human primates. A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus) Roshini Sathiaseelan, Jose V V Isola, Roberto Santín-Márquez, Daniel Adekunbi, Michal Fornalik, Adam B Salmon, […]
March 4, 2025
The lab of Blake Rasmussen, PhD collaborated with the late Mike Sheetz, PhD lab to Rejuvenate Senescent Cells with low frequency ultrasound. Dr. Rasmussen is Professor and Chair of the Department of Cellular & Integrative Physiology, Director of the Center for Metabolic Health, and an investigator with the Sam And Ann Barshop Institute for Longevity […]
February 27, 2025
A new study from the lab of Blake Rasmussen, PhD has identified new functional regulators of the differences in exercise response between young and old men. These might be future targets to improve exercise output in older populations. Dr. Rasmussen is Professor and Chair of the Department of Cellular & Integrative Physiology, Director of the […]
February 26, 2025
Congratulations to the lab of Dr. David Gius. His lab’s recent publication outlines how the regulation of mitochondrial antioxidant MnSOD drives mitochondrial physiology and heart dysfunction. Dr. Gius is a Professor of Radiation Oncology, the Assistant Dean for Research with the Joe R. & Teresa Lozano Long School of Medicine, and the Associate Cancer Center […]
February 25, 2025
Newest publication from the lab of Lily Dong, PhD, identifies a new player in the regulation of metabolic function. The hormone LRG1 is a significant contributor to diet-induced diabetes in animal models and may be a promising therapeutic target. Dr. Dong is Professor and Chair of the Department of Cell Systems and Anatomy. Diet-enhanced LRG1 […]
February 19, 2025
Congratulations to the lab of Dr. Ann Griffith. Their work demonstrates how the thymus is protected during aging by FGF21, providing potential targets for immune aging. Dr. Griffith is an Assistant Professor in the Department of Microbiology, Immunology & Molecular Genetics. Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan Sarah […]
