The paper, titled “Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD mice,” explores how microglia, the brain’s immune cells, regulate lipid metabolism and contribute to Alzheimer’s disease progression. By studying microglial depletion in a mouse model of Alzheimer’s, the research provides new insights into how these cells influence disease […]

Dr. Juan Pablo Palavicini has received a Rising UT STAR retention award for $150,000. The STARs (Science and Technology Acquisition and Retention) Program provides funding to help purchase state-of-the-art equipment and make necessary laboratory/facility renovations to support faculty members in performing their research.  Dr. Palavicini is an assistant professor in the Department of Cellular and […]

Study Highlights Sex-Specific Impact of Keto Diet A recent study from the lab of David Gius, MD, PhD, and published in Cell Reports reveals that a long-term ketogenic diet leads to the accumulation of aging (senescent) cells and oxidative stress—but only in male mice. Female mice did not show these harmful effects. Interestingly, treating male […]

Nisi Jiang, PhD, first author and recent Biology of Aging IBMS graduate under the mentorship of James Nelson, PhD, led the first-ever comprehensive review of anti-aging compounds tested by the National Institute on Aging’s Interventions Testing Program. Published in the Journal of Gerontology: Biological Science (July 2025), the landmark study analyzed two decades of data […]

Original story: Texas Public Radio By: Bonnie Petrie (August 24, 2025) ­— A recent review of two decades of research from the National Institute on Aging (NIA) highlighted 13 anti-aging medications that show promise in preclinical studies for significantly extending lifespan. More than that, they seem to improve the quality of those extra years. There’s […]

Highlights: This review explores ferroptosis, an iron-dependent, non-apoptotic form of programmed cell death, as a promising strategy for eliminating senescent cells, which accumulate with age and contribute to tissue dysfunction and age-related diseases such as fibrosis, atherosclerosis, osteoarthritis, and neurodegeneration. The molecular mechanisms of ferroptosis, including iron overload, lipid peroxidation, and oxidative damage, can be […]