News

February 4, 2019

Rapamycin and Alzheimer’s disease: Time for a clinical trial? Kaeberlein M, Galvan V Sci Transl Med. 2019 Jan 23;11(476). pii: eaar4289. doi: 10.1126/scitranslmed.aar4289. Abstract: The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer’s disease. Despite its compelling preclinical record, no clinical trials have […]

February 4, 2019

Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF‐16 in C. elegans. Aiping Xu, Zhao Zhang, Su‐Hyuk Ko, Alfred L. Fisher, Zhijie Liu, Lizhen Chen Aging Cell. 14 January 2019. doi: 10.1111/acel.12884. [Epub ahead of print]. Abstract: Microtubule (MT) regulation is involved in both neuronal function and the maintenance […]

January 22, 2019

Dr. Frost was recognized as a Junior Research Scholar. https://news.uthscsa.edu/congratulations-to-the-2019-presidential-awards-winners/

December 19, 2018

Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB American Journal of Primatology. 2018 Oct 12:e22927. doi: 10.1002/ajp.22927. [Epub ahead of print]. Abstract: Interventions to extend lifespan and improve health with increasing age would have significant impact […]

December 18, 2018

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, […]

December 14, 2018

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp. Blanco CL, Gastaldelli A, Anzueto DG, Winter LA, Seidner SR, McCurnin DC, Liang H, Javors MA, DeFronzo RA, Musi N PLoS one. 2018 Dec 12;13(12):e0208757. doi: 10.1371/journal.pone.0208757. eCollection 2018. Abstract: Premature baboons exhibit peripheral insulin resistance and impaired […]

December 14, 2018

NFκB Regulates Muscle Development and Mitochondrial Function. Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N J Gerontol A Biol Sci Med Sci. 2018 Nov 13. doi: 10.1093/gerona/gly262. [Epub ahead of print] Abstract: NFκB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated […]

December 14, 2018

Dr. Galvan has been recently elected as President-Elect-Elect of the American Aging Association (AGE)! She will be organizing the 50th Annual Meeting and Anniversary Celebration of AGE in San Antonio in 2021.

November 12, 2018

Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila Cornelison GL, Levy SA, Jenson T, Frost B Aging Cell. 2018 Nov 9:e12847. doi: 10.1111/acel.12847. [Epub ahead of print] Abstract: The nucleus is a spherical dual-membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and […]

October 26, 2018

Marmoset as a model to study kidney changes associated with aging. Lee HJ, Gonzalez O, Dick EJ Jr, Donati A, Feliers D, Goutam Ghosh C, Ross C, Venkatachalam M, Tardif SD, Kasinath BS J Gerontol A Biol Sci Med Sci. 2018 Oct 13. doi: 10.1093/gerona/gly237. [Epub ahead of print] DOI: 10.1093/gerona/gly237 Abstract: We evaluated whether […]