David Gius, MD, PhD, professor in the Department of Radiation Oncology, received CPRIT’s individual investigator research award for clinical trials in the amount of $1,390,420 to fund a four-year, phase 2 clinical trial for women with estrogen receptor positive (ER+) breast cancer. UT Health Newsroom Press Release CPRIT Press Release

Masahiro Morita, PhD, associate professor in the Department of Molecular Medicine and a researcher with the Sam and Ann Barshop Institute for Longevity and Aging Studies at UT Health San Antonio, received a $900,000 individual investigator award from CPRIT to study how obesity increases the risk of liver cancer by investigating the mechanisms by which […]

The lab of Blake Rasmussen, PhD collaborated with the late Mike Sheetz, PhD lab to Rejuvenate Senescent Cells with low frequency ultrasound.  Dr. Rasmussen is Professor and Chair of the Department of Cellular & Integrative Physiology, Director of the Center for Metabolic Health, and an investigator with the Sam And Ann Barshop Institute for Longevity […]

A new study from the lab of Blake Rasmussen, PhD has identified new functional regulators of the differences in exercise response between young and old men.  These might be future targets to improve exercise output in older populations.  Dr. Rasmussen is Professor and Chair of the Department of Cellular & Integrative Physiology, Director of the […]

Congratulations to the lab of Dr. David Gius. His lab’s recent publication outlines how the regulation of mitochondrial antioxidant MnSOD drives mitochondrial physiology and heart dysfunction.  Dr. Gius is a Professor of Radiation Oncology, the Assistant Dean for Research with the Joe R. & Teresa Lozano Long School of Medicine, and the Associate Cancer Center […]

Newest publication from the lab of Lily Dong, PhD, identifies a new player in the regulation of metabolic function. The hormone LRG1 is a significant contributor to diet-induced diabetes in animal models and may be a promising therapeutic target.  Dr. Dong is Professor and Chair of the Department of Cell Systems and Anatomy. Diet-enhanced LRG1 […]

Unsheathing the role of myelin lipids in Alzheimer’s disease By Andrea Lius Feb. 21, 2025 Alzheimer’s disease, or AD, is a devastating neurodegenerative disease that leads to irreversible cognitive decline in older adults. In the early 2000s, Xianlin Han and his colleagues found that patients with early AD had dramatically reduced levels of sulfatides, a […]

Congratulations to the lab of Dr. Ann Griffith. Their work demonstrates how the thymus is protected during aging by FGF21, providing potential targets for immune aging.  Dr. Griffith is an Assistant Professor in the Department of Microbiology, Immunology & Molecular Genetics. Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan Sarah […]

The manuscript, “A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice,” was published in Nature Aging. In the paper, they reported the discovery of the first liver tropic senolytic BCL-xL and BCL-2 PROTAC 753b, which can selectively reduce senescent cells in the liver in aged mice and […]