Barshop Institute
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February 21, 2025
Unsheathing the role of myelin lipids in Alzheimer’s disease By Andrea Lius Feb. 21, 2025 Alzheimer’s disease, or AD, is a devastating neurodegenerative disease that leads to irreversible cognitive decline in older adults. In the early 2000s, Xianlin Han and his colleagues found that patients with early AD had dramatically reduced levels of sulfatides, a […]
February 19, 2025
Congratulations to the lab of Dr. Ann Griffith. Their work demonstrates how the thymus is protected during aging by FGF21, providing potential targets for immune aging. Dr. Griffith is an Assistant Professor in the Department of Microbiology, Immunology & Molecular Genetics. Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan Sarah […]
February 14, 2025
The manuscript, “A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice,” was published in Nature Aging. In the paper, they reported the discovery of the first liver tropic senolytic BCL-xL and BCL-2 PROTAC 753b, which can selectively reduce senescent cells in the liver in aged mice and […]
February 7, 2025
Dr. Shangang Zhao has been selected as a recipient of a 2025 Presidential Excellence Award in the category of Junior Research Scholar. Established in 1985, the Presidential Awards recognize exemplary performance by individuals who consistently excel in their positions and demonstrate a strong commitment to the mission and core values of UT Health San Antonio. […]
February 5, 2025
The outcomes of this study suggest that targeting the cGAS-STING signaling pathway is a potential therapeutic strategy for Alzheimer’s disease. Dr. Xianlin Han is a professor in the Department of Medicine, Division of Diabetes and an investigator with the Sam and Ann Barshop Institute for Longevity and Aging Studies. Dr. Sijia He is an Assistant […]
January 28, 2025
Their study characterizes the role of adiponectin in the development of age-related liver fibrosis. Dr. Zhao is an assistant professor in the Department of Medicine, Division of Endocrinology and an investigator with the Sam and Ann Barshop Institute for Longevity and Aging Studies. The adiponectin-PPARγ axis in hepatic stellate cells regulates liver fibrosis Shangang Zhao, […]
January 27, 2025
Their study identifies the process of ferroptosis as a potential target to preserve neuronal function and innervation with aging. Dr. Chen is the holder of the Bartell Zachry Memorial Distinguished Professorship for Research in Neurodegenerative Diseases, an Associate Professor with the Department of Cell Systems and Anatomy, and an investigator with the Sam and Ann […]
January 6, 2025
Original story: Texas Public Radio By: Bonnie Petrie (January 5, 2025) — This segment was originally broadcast on July 7, 2024. Exercise impacts men and women differently. That’s one of the conclusions of a study published in early May in “Nature” that used data gathered at UT Health San Antonio. It’s part of a nationwide, […]
November 15, 2024
Dr. Jun Zhang has received an R03 grant from the National Institutes of Health for the project titled “Pathological cardiolipin remodeling links mitochondrial dysfunction to inflammaging.” Dr. Zhang is an Assistant Professor/Research with the Sam and Ann Barshop Institute for Longevity and Aging Studies and the Department of Pharmacology.
October 3, 2024
Dr. Lizhen Chen has been appointed as the Holder of the Bartell Zachry Memorial Distinguished Professorship for Research in Neurodegenerative Diseases, endowment #57700662, effective 8/1/2024 – 7/31/2029. Dr. Chen is an Associate Professor with the Sam and Ann Barshop Institute for Longevity and Aging Studies and the Department of Cell Systems and Anatomy.