Barshop Institute
May 14, 2025
Erik Marchant, a third year PhD student, has published his first paper from his dissertation. Erik used low-frequency ultrasound in old mice with insulin resistance and diabetes and discovered many interesting transcriptomic changes in skeletal muscle that reduce inflammation and alter immune cell function. Erik is a PhD student in the lab of Blake Rasmussen, […]
May 5, 2025
Sean Kilroe, PhD, has published his first paper as a postdoctoral fellow in the lab of Blake Rasmussen, PhD. Dr. Kilroe used a multi-omics approach to outline which metabolic pathways are impacted in human skeletal muscle in response to physical inactivity. Dr. Rasmussen is Professor and Chair of the Department of Cellular & Integrative Physiology, […]
April 19, 2025
Original story: UT Health San Antonio Newsroom Discovery of chemical endocytosis could redefine precision medicine Contact: Claire Kowalick, kowalick@uthscsa.edu SAN ANTONIO (April 18, 2025) — A team of scientists, notably Zhengyu Wang, PhD, assistant professor in the department of pharmacology and the Barshop Institute, led by Hong-yu Li, PhD, professor of medicinal chemistry and chemical […]
April 15, 2025
Anya Kalenta, a final year PhD student, has published her first first-author publication. In this study, they investigated how an acute bout of treadmill running alters the skeletal muscle metabolome and lipidome in mice with hyperactive mTORC1 signaling. Anya is a PhD student in the lab of Blake Rasmussen, PhD at the Sam and Ann […]
April 7, 2025
In new research supported by the San Antonio Nathan Shock Center, Yidong Bai, PhD, shows that the structure and function of mitochondria of naked mole-rats are preserved with age. The preservation of mitochondria assembly might contribute to the extreme longevity and disease resistance of these animals. Robust assembly of electron transfer chain in the brain […]
March 31, 2025
A new publication from Daniel Adekunbi, PhD, shows that aging is associated with a significant decline in mitochondrial bioenergetics in the brain in a non-human primate model of aging. This loss of energetics is associated with a similar decline in walking speed with age, highlighting a potential mechanism for increased frailty and loss of function […]
March 27, 2025
A new study from the lab of Kevin Koronowski, PhD, looks at the effect of chronic jet lag in mice on their behavior and metabolism dysfunction in the liver. This study shows that misalignment of the normal circadian rhythm can have long-term functional consequences that may deteriorate aging health. Dr. Koronowski is an Assistant Professor […]
March 19, 2025
A new paper from the lab of David Gius, MD, PhD, and supported by the Shock Center GeroMetabolism Core, uses a novel mouse model targeting mitochondrial acetylation to identify potential functional mechanisms of ketogenic diets on lipid metabolism. Dr. Gius is a Professor of Radiation Oncology, the Assistant Dean for Research with the Joe R. […]
March 18, 2025
Congratulations to Pepper Center Core Leader Tiffany Cortes, MD, on her new paper outlining the importance of addressing lifestyle-based approaches to preserving bone and muscle with weight loss in older patients and identify best practices for doing so. Dr. Cortes is an Assistant Professor/Clinical in the Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes. […]
March 12, 2025
Support from the San Antonio Nathan Shock Center Animal Core contributed to a recent publication of translation of 17α-estradiol as a gerotherapeutic intervention in non-human primates. A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus) Roshini Sathiaseelan, Jose V V Isola, Roberto Santín-Márquez, Daniel Adekunbi, Michal Fornalik, Adam B Salmon, […]