Barshop Institute
Category
December 4, 2025
Original story: UT Health San Antonio Newsroom By Claire Kowalick SAN ANTONIO (December 3, 2025) A University of Texas at San Antonio scientist has been awarded a junior faculty grant from the American Federation for Aging Research, or AFAR. Sijia He, PhD, assistant professor in the Department of Cellular and Integrative Physiology in the Joe […]
November 21, 2025
Highlights: The paper reviews evidence on lifestyle-based weight loss in older adults with obesity, showing that caloric restriction reliably reduces fat mass but often leads to concurrent losses in muscle and bone. It identifies resistance training, adequate protein intake, and vitamin D supplementation as the most effective strategies to preserve musculoskeletal health during weight loss, […]
November 20, 2025
A new paper from the Interventions Testing Program (ITP) provides an analytic tool that is more sensitive to geroprotective drug effects on lifespan and, ultimately, health span than current statistical tools, indicating when during treatment/lifespan, for how long, and at what effect size the intervention (drug, genetic, nutritional) reduces age-specific mortality thereby increasing lifespan potential. […]
November 19, 2025
Original story: UT Health San Antonio Newsroom By Claire Kowalick and Amanda Cerreto SAN ANTONIO (November 18, 2025) The University of Texas at San Antonio has secured federal funding for a new research hub dedicated to studying Alzheimer’s disease and related dementias, propelling the university into the ranks of leading research institutions in the United […]
October 23, 2025
The paper, titled “Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD mice,” explores how microglia, the brain’s immune cells, regulate lipid metabolism and contribute to Alzheimer’s disease progression. By studying microglial depletion in a mouse model of Alzheimer’s, the research provides new insights into how these cells influence disease […]
October 3, 2025
Original story: UT Health San Antonio Newsroom By Claire Kowalick SAN ANTONIO (October 2, 2025) It is often said that exercise is the best medicine, but for many older adults, it can be a prescription that is increasingly difficult to take. Age-related physical and mental health challenges frequently make regular activity hard to sustain. A […]
September 21, 2025
A new study from the lab of Shangang Zhao, PhD, shows increased susceptibility of older mice to side effects when treated with liraglutide (a GLP-1 receptor agonist to treat obesity and metabolic disease). From this study, on-off cycles of this drug cause acceleration of frailty and sarcopenia. Dr. Zhao is an Assistant Professor in the […]
September 20, 2025
A new study from Ellen Kraig, PhD, and Dean Kellogg, Jr, MD, PhD, reports on the benefits of the gerotherapeutic rapamycin to cardiac and endothelial function in aging patients. This pilot study was supported by the San Antonio Claude Pepper Older Americans Independence Center. Dr. Kraig is a Professor in the Department of Cell Systems […]
September 19, 2025
A new study from the Interventions Testing Program (ITP) highlights beneficial effects on mouse lifespan with the compounds epicatechin (a plant compound in cocoa, red wine, and tea), halofuginone (a protein synthesis inhibitor) and mitoglitazone (an insulin sensitizer). The Barshop Institute is one of 3 sites that make up the ITP. Extension of lifespan by […]
September 15, 2025
Original story: UT Health San Antonio Newsroom Shared By: Claire Kowalick SAN ANTONIO (September 15, 2025) — The population of older Americans is expanding rapidly and is expected to double by 2060. While people are living longer than ever, many are also living with chronic health problems that impact their quality of life and ability […]